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Treffer: Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Title:
Germline variation at 8q24 and prostate cancer risk in men of European ancestry
Authors:
Matejcic, Marco, Saunders, Edward J., Dadaev, Tokhir, Brook, Mark N., Wang, Kan, Sheng, Xin, Olama, Ali Amin Al, Schumacher, Fredrick R., Ingles, Sue A., Govindasami, Koveela, Benlloch, Sara, Berndt, Sonja I., Albanes, Demetrius, Koutros, Stella, Muir, Kenneth, Stevens, Victoria L., Gapstur, Susan M., Tangen, Catherine M., Batra, Jyotsna, Clements, Judith, Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Kraft, Peter, Cancel-Tassin, Géraldine, Sorensen, Karina D., Maehle, Lovise, Grindedal, Eli M., Strom, Sara S., Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Rosenstein, Barry, Lu, Yong-Jie, Giles, Graham G., Kibel, Adam S., Vega, Ana, Bensen, Jeanette T., Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Brenner, Hermann, Maier, Christiane, Kim, Jeri, Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Gago-Dominguez, Manuela, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa A., Pandha, Hardev, Thibodeau, Stephen N., Schaid, Daniel J., Henderson, Brian E., Stern, Mariana C., Thwaites, Alison, Guy, Michelle, Whitmore, Ian, Morgan, Angela, Fisher, Cyril, Hazel, Steve, Livni, Naomi, Cook, Margaret, Fachal, Laura, Weinstein, Stephanie, Beane Freeman, Laura E., Hoover, Robert N., Machiela, Mitchell J., Lophatananon, Artitaya, Carter, Brian D., Goodman, Phyllis J., Moya, Leire, Srinivasan, Srilakshmi, Kedda, Mary-Anne, Yeadon, Trina, Eckert, Allison, Eklund, Martin, Cavalli-Bjoerkman, Carin, Dunning, Alison M., Sipeky, Csilla, Hakansson, Niclas, Elliott, Rebecca, Ranu, Hardeep, Giovannucci, Edward, Turman, Constance, Hunter, David J., Cussenot, Olivier, Orntoft, Torben Falck, Lane, Athene, Lewis, Sarah J., Davis, Michael, Key, Tim J., Brown, Paul, Kulkarni, Girish S., Zlotta, Alexandre R., Fleshner, Neil E., Finelli, Antonio, Mao, Xueying, Marzec, Jacek, MacInnis, Robert J., Milne, Roger, Hopper, John L., Aguado, Miguel, Bustamante, Mariona, Castaño-Vinyals, Gemma, Gracia-Lavedan, Esther, Cecchini, Lluís, Stampfer, Meir, Ma, Jing, Sellers, Thomas A., Geybels, Milan S., Park, Hyun, Zachariah, Babu, Kolb, Suzanne, Wokolorczyk, Dominika, Lubinski, Jan, Kluzniak, Wojciech, Nielsen, Sune F., Weisher, Maren, Cuk, Katarina, Vogel, Walther, Luedeke, Manuel, Logothetis, Christopher J. J., Paulo, Paula, Cardoso, Marta, Maia, Sofia, Silva, Maria P., Steele, Linda, Ding, Yuan Chun, De Meerleer, Gert, De Langhe, Sofie, Thierens, Hubert, Lim, Jasmine, Tan, Meng H., Ong, Aik T., Lin, Daniel W., Kachakova, Darina, Mitkova, Atanaska, Mitev, Vanio, Parliament, Matthew, Jenster, Guido, Bangma, Christopher, Schroder, F. H., Truong, Thérèse, Koudou, Yves Akoli, Michael, Agnieszka, Kierzek, Andrzej, Karlsson, Ami, Broms, Michael, Wu, Huihai, Aukim-Hastie, Claire, Tillmans, Lori, Riska, Shaun, McDonnell, Shannon K., Dearnaley, David, Spurdle, Amanda, Gardiner, Robert, Hayes, Vanessa, Butler, Lisa, Taylor, Renea, Papargiris, Melissa, Saunders, Pamela, Kujala, Paula, Talala, Kirsi, Taari, Kimmo, Bentzen, Søren, Hicks, Belynda, Vogt, Aurelie, Hutchinson, Amy, Cox, Angela, George, Anne, Toi, Ants, Evans, Andrew, van der Kwast, Theodorus H., Imai, Takashi, Saito, Shiro, Zhao, Shan-Chao, Ren, Guoping, Zhang, Yangling, Yu, Yongwei, Wu, Yudong, Wu, Ji, Zhou, Bo, Pedersen, John, Lobato-Busto, Ramón, Ruiz-Dominguez, José Manuel, Mengual, Lourdes, Alcaraz, Antonio, Pow-Sang, Julio, Herkommer, Kathleen, Vlahova, Aleksandrina, Dikov, Tihomir, Christova, Svetlana, Carracedo, Angel, Tretarre, Brigitte, Rebillard, Xavier, Mulot, Claire, Adolfsson, Jan, Stattin, Par, Johansson, Jan-Erik, Martin, Richard M., Thompson, Ian M., Chambers, Suzanne, Aitken, Joanne, Horvath, Lisa, Haynes, Anne-Maree, Tilley, Wayne, Risbridger, Gail, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Tammela, Teuvo L. J., Murtola, Teemu, Auvinen, Anssi, Burnet, Neil, Barnett, Gill, Andriole, Gerald, Klim, Aleksandra, Drake, Bettina F., Borre, Michael, Kerns, Sarah, Ostrer, Harry, Zhang, Hong-Wei, Cao, Guangwen, Lin, Ji, Ling, Jin, Li, Meiling, Feng, Ninghan, Li, Jie, He, Weiyang, Guo, Xin, Sun, Zan, Wang, Guomin, Guo, Jianming, Southey, Melissa C., Fitzgerald, Liesel M., Marsden, Gemma, Gómez-Caamaño, Antonio, Carballo, Ana, Peleteiro, Paula, Calvo, Patricia, Szulkin, Robert, Llorca, Javier, Dierssen-Sotos, Trinidad, Gómez Acebo, Inés, Lin, Hui-Yi, Ostrander, Elaine A., Bisbjerg, Rasmus, Klarskov, Peter, Røder, Martin Andreas, Iversen, Peter, Holleczek, Bernd, Stegmaier, Christa, Schnoeller, Thomas, Bohnert, Philipp, John, Esther M., Ost, Piet, Teo, Soo-Hwang, Gamulin, Marija, Kulis, Tomislav, Kastelan, Zeljko, Slavov, Chavdar, Popov, Elenko, Van den Broeck, Thomas, Joniau, Steven, Larkin, Samantha, Castelao, Jose Esteban, Martinez, Maria Elena, van Schaik, Ron H. N., Xu, Jianfeng, Lindström, Sara, Riboli, Elio, Berry, Clare, Siddiq, Afshan, Canzian, Federico, Kolonel, Laurence N., Le Marchand, Loic, Freedman, Matthew, Cenee, Sylvie, Sanchez, Marie, Wiklund, Fredrik, Chanock, Stephen J., Easton, Douglas F., Eeles, Rosalind A., Kote-Jarai, Zsofia, Conti, David V., Haiman, Christopher A.
Contributors:
Universidad de Cantabria, De Meerleer, Gert, Keck School of Medicine [Los Angeles], University of Southern California (USC), The institute of cancer research [London], Department of Clinical Neurosciences [Cambridge], University of Cambridge [UK] (CAM), Centre for Cancer Genetic Epidemiology [Cambridge], Department of Oncology-University of Cambridge [UK] (CAM), Case Western Reserve University [Cleveland], National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Warwick Medical School, University of Warwick [Coventry], University of Manchester [Manchester], Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology [Brisbane] (QUT), Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet [Stockholm], University College of London [London] (UCL), University of Turku, University of Tampere [Finland], The Institute of Environmental Medicine [Stockholm] (IMM), Manchester Academic Health Science Centre (MAHSC), Harvard School of Public Health, Harvard T.H. Chan School of Public Health, Université Pierre et Marie Curie - Paris 6 (UPMC), Aarhus University Hospital, Aarhus University [Aarhus], Oslo University Hospital [Oslo], The University of Texas M.D. Anderson Cancer Center [Houston], Addenbrooke's Hospital, Cambridge University NHS Trust, University of Oxford [Oxford], School of Social and Community Medicine [Bristol], University of Bristol [Bristol], Icahn School of Medicine at Mount Sinai [New York] (MSSM), Centre for Molecular Oncology and Imaging, Centre for Molecular Oncology and Imaging, Barts Cancer Institute, Queen Mary University of London (QMUL), University of Melbourne, Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), CIBER de Enfermedades Raras (CIBERER), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Universitat Pompeu Fabra [Barcelona] (UPF), University of Washington [Seattle], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), National Center for Tumor Diseases [Dresden] (NCT), Technische Universität Dresden = Dresden University of Technology (TU Dresden)-German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ)-Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Universität Ulm - Ulm University [Ulm, Allemagne], Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Universiteit Gent = Ghent University [Belgium] (UGENT), University of Malaya [Kuala Lumpur, Malaisie], Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), University of Alberta, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University of California [San Diego] (UC San Diego), University of California, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris-Saclay, University of Utah School of Medicine [Salt Lake City], University of Surrey (UNIS), Mayo Clinic [Rochester], Royal Marsden NHS Foundation Trust, Dadaev, Tokhir [0000-0002-8268-0438], Brook, Mark N [0000-0002-8969-2378], Wang, Kan [0000-0002-0640-6058], Olama, Ali Amin Al [0000-0002-7178-3431], Schumacher, Fredrick R [0000-0002-3073-7463], Muir, Kenneth [0000-0001-6429-988X], Batra, Jyotsna [0000-0003-4646-6247], Pashayan, Nora [0000-0003-0843-2468], Schleutker, Johanna [0000-0002-1863-0305], Wolk, Alicja [0000-0001-7387-6845], Cancel-Tassin, Géraldine [0000-0002-9583-6382], Sorensen, Karina D [0000-0002-4902-5490], Lessel, Davor [0000-0003-4496-244X], Roobol, Monique J [0000-0001-6967-1708], Chanock, Stephen J [0000-0002-2324-3393], Easton, Douglas F [0000-0003-2444-3247], Eeles, Rosalind A [0000-0002-3698-6241], Apollo - University of Cambridge Repository, University of Cambridge [UK] (CAM)-Department of Oncology, University of Oxford, Universidade do Porto = University of Porto, Universiteit Gent = Ghent University (UGENT), University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), University of California (UC), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Gestionnaire, Hal Sorbonne Université, Urology, University Management, Clinicum, HUS Abdominal Center
Source:
Nature Communications
Nat Commun. 2018 Nov 5;9(1):4616
PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium 2018, ' Germline variation at 8q24 and prostate cancer risk in men of European ancestry ', Nature Communications, vol. 9, no. 1 . https://doi.org/10.1038/s41467-018-06863-1
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-06863-1⟩
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Matejcic, M, Saunders, E J, Dadaev, T, Brook, M N, Wang, K, Sheng, X, Olama, A A A, Schumacher, F R, Ingles, S A, Govindasami, K, Benlloch, S, Berndt, S I, Albanes, D, Koutros, S, Muir, K, Stevens, V L, Gapstur, S M, Tangen, C M, Batra, J, Clements, J, Gronberg, H, Pashayan, N, Schleutker, J, Wolk, A, West, C, Mucci, L, Kraft, P, Cancel-Tassin, G, Sorensen, K D, Maehle, L, Grindedal, E M, Strom, S S, Neal, D E, Hamdy, F C, Donovan, J L, Travis, R C, Hamilton, R J, Rosenstein, B, Lu, Y J, Giles, G G, Kibel, A S, Vega, A, Bensen, J T, Kogevinas, M, Penney, K L, Park, J Y, Stanford, J L, Cybulski, C, Nordestgaard, B G, Brenner, H & PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium 2018, ' Germline variation at 8q24 and prostate cancer risk in men of European ancestry ', Nature Communications, vol. 9, 4616 . https://doi.org/10.1038/s41467-018-06863-1
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06863-1⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, 9:4616. Nature Publishing Group
Publisher Information:
Nature Research, 2018.
Publication Year:
2018
Subject Terms:
0301 basic medicine, Oncology, Male, [SDV]Life Sciences [q-bio], LOCI, General Physics and Astronomy, Genome-wide association study, PROGRESSION, [SDV.GEN] Life Sciences [q-bio]/Genetics, MYC, SUSCEPTIBILITY, UP-REGULATION, Prostate cancer, Risk Factors, Genotype, Urologi och njurmedicin, Medicine, lcsh:Science, Pròstata -- Càncer, education.field_of_study, RARE VARIANT, Multidisciplinary, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Manchester Cancer Research Centre, LONG NONCODING RNA, Chromosome Mapping, Men, 3. Good health, [SDV] Life Sciences [q-bio], Multidisciplinary Sciences, Science & Technology - Other Topics, Disease Susceptibility, Risk assessment, Chromosomes, Human, Pair 8, Genetic Markers, medicine.medical_specialty, Science, 3122 Cancers, Population, [SDV.CAN]Life Sciences [q-bio]/Cancer, Risk Assessment, Article, General Biochemistry, Genetics and Molecular Biology, White People, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, SDG 3 - Good Health and Well-being, Internal medicine, Genetics, Urology and Nephrology, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, education, Author Correction, METAANALYSIS, [SDV.GEN]Life Sciences [q-bio]/Genetics, Cancer och onkologi, Science & Technology, Càncer de pròstata, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Case-control study, Cancer, Prostatic Neoplasms, General Chemistry, 3126 Surgery, anesthesiology, intensive care, radiology, medicine.disease, 030104 developmental biology, Homes, Haplotypes, Cancer and Oncology, Case-Control Studies, lcsh:Q, Population Risk, business, Genètica, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
File Description:
text; application/pdf; Electronic
Language:
English
ISSN:
2041-1723
Rights:
OPEN
Accession Number:
edsair.doi.dedup.....79b75503a3e22f7b4ccc4372ef773086
Database:
OpenAIRE

Weitere Informationen

Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p
Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.