• Function of the Human Cingulat...

*Result*: Function of the Human Cingulate Cortex: A Brainnetome Atlas-Based Study via Cortical Electrical Stimulation in Patients With Epilepsy.

Title:
Function of the Human Cingulate Cortex: A Brainnetome Atlas-Based Study via Cortical Electrical Stimulation in Patients With Epilepsy.
Authors:
Deng Q; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Wang M; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Chen G; Beijing Key Laboratory of Behavior and Mental Health, School of Psychological and Cognitive Sciences, Peking University, Beijing, China.; IDG/McGovern Institute for Brain Research, Peking University, Beijing, China., Wang X; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Yan Z; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Yang H; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Yang Y; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Wang M; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Guo M; Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Xiong Z; Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Guan N; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Zhou J; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Guan Y; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Luan G; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China., Li T; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University, Beijing, China.; Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.; Laboratory for Clinical Medicine, Capital Medical University, Beijing, China., Wang J; Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.; Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Source:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2026 Jan; Vol. 32 (1), pp. e70768.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
Imprint Name(s):
Original Publication: Oxford, UK : Wiley-Blackwell, c2008-
MeSH Terms:
Gyrus Cinguli*/physiopathology , Gyrus Cinguli*/physiology , Gyrus Cinguli*/diagnostic imaging , Drug Resistant Epilepsy*/physiopathology , Drug Resistant Epilepsy*/diagnostic imaging, Electric Stimulation/methods ; Brain Mapping/methods ; Epilepsy/physiopathology ; Humans ; Male ; Female ; Adult ; Young Adult ; Retrospective Studies ; Middle Aged ; Adolescent ; Electroencephalography
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Grant Information:
CU-2023-052 CAAE Epilepsy Research Fund-UCB Fund; CB-2022-017 CAAE-Neuracle Neuroelectrics Research Fund; 2022ZD0205000 STI2030-Major Projects; 32020103009 the National Natural Science Foundation of China; 2024-2-6011 Capital's Health Development Research Fund
Contributed Indexing:
Keywords: Brainnetome atlas; cingulate cortex; cortical electrical stimulation; drug‐resistant epilepsy; functional mapping
Entry Date(s):
Date Created: 20260123 Date Completed: 20260123 Latest Revision: 20260126
Update Code:
20260130
PubMed Central ID:
PMC12828339
DOI:
10.1002/cns.70768
PMID:
41572956
Database:
MEDLINE

*Further Information*

*Objective: This study aimed to systematically map the functional organization of the cingulate gyrus using cortical electrical stimulation (CES) guided by the Brainnetome Atlas.
Methods: We retrospectively analyzed CES data from 234 patients with drug-resistant epilepsy who underwent stereoelectroencephalography (SEEG) implantation in the cingulate cortex. A total of 1141 stimulation sites across seven cingulate subregions (A23d, A24rv, A32p, A23v, A24cd, A23c, A32sg) were examined. Responses were categorized into somatosensory, motor, autonomic, vestibular, visual, emotional, memory, and pain-related phenomena.
Results: Key findings included: (1) Somatosensory responses (n = 99) were widely distributed, with motor responses localized to middle-posterior subregions (A23c/A24rv/A24cd); (2) Autonomic (n = 58) and emotional (n = 15) responses showed broad distribution, with ventral MCC (A24rv) as an affective hub; (3) Pain responses (n = 30) involved both anterior (affective) and posterior (spatial) subregions; (4) Memory deficits (n = 8) specifically localized to posterior cingulate (A23d); (5) Visual (n = 13) and vestibular (n = 51) responses clustered in posterior and middle-posterior regions, respectively.
Conclusion: This study provides a systematic functional mapping of the cingulate gyrus using the Brainnetome Atlas, demonstrating its integrated role in diverse neurological functions. The findings advance understanding of cingulate pathophysiology and have implications for surgical planning in epilepsy.
(© 2026 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)*