• Letter Distortion Mapping in A...

*Result*: Letter Distortion Mapping in Amblyopia: Spatial Patterns, Stability, and Relationship to Visual Acuity.

Title:
Letter Distortion Mapping in Amblyopia: Spatial Patterns, Stability, and Relationship to Visual Acuity.
Authors:
Molaei H; McGill Vision Research Unit, Department of Ophthalmology & Visual Sciences, Montréal General Hospital, Montreal, Quebec, Canada., Abbas Farishta R; McGill Vision Research Unit, Department of Ophthalmology & Visual Sciences, Montréal General Hospital, Montreal, Quebec, Canada., Farivar R; McGill Vision Research Unit, Department of Ophthalmology & Visual Sciences, Montréal General Hospital, Montreal, Quebec, Canada.; Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
Source:
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2025 Dec 01; Vol. 66 (15), pp. 65.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Print Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE
Imprint Name(s):
Publication: Brookline Ma : Association For Research In Vision And Ophthalmology (Arvo)
Original Publication: St. Louis, Mosby.
MeSH Terms:
Amblyopia*/physiopathology , Visual Acuity*/physiology , Pattern Recognition, Visual*/physiology, Humans ; Male ; Female ; Adult ; Middle Aged ; Young Adult ; Visual Fields/physiology ; Adolescent
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Entry Date(s):
Date Created: 20260114 Date Completed: 20260114 Latest Revision: 20260118
Update Code:
20260130
PubMed Central ID:
PMC12742594
DOI:
10.1167/iovs.66.15.65
PMID:
41533934
Database:
MEDLINE

*Further Information*

*Purpose: To investigate whether letter-based perceptual distortions in amblyopia follow spatially consistent patterns across different letters and to determine if these spatial distortion maps are letter specific or reflect a common underlying spatial organization of visual distortion in the amblyopic eye.
Methods: Twenty-one individuals with amblyopia completed a distortion mapping task using the letters A, D, and E, shown at 36 visual field locations. Each letter was first viewed with the fellow eye and then with the amblyopic eye. Participants reported distortions, which were recorded to generate binary spatial maps. The task was repeated over three sessions to assess within-subject consistency, and spatial correlations were analyzed across letters and subjects.
Results: Letter distortions were reported by 95% of participants and remained consistent across sessions. Within subjects, spatial distortion maps were significantly correlated across letters in 62% of cases (P ≤ 0.028), suggesting shared spatial patterns. However, across subjects, maps were largely uncorrelated, indicating individualized distortion profiles. No single letter consistently showed more distortion across the group, χ2(2) = 1.279, P = 0.5. A strong positive correlation was found between interocular visual acuity difference and overall distortion intensity (r = 0.70, P < 0.001), consistent across all letters.
Conclusions: Letter distortions in amblyopia are highly prevalent, reliable, and spatially organized within individuals but idiosyncratic across subjects. These distortions correlate strongly with visual acuity loss, highlighting their potential as a clinically valuable and perceptually relevant measure for characterizing amblyopic visual dysfunction.*