• Transcriptomic analysis reveal...

*Result*: Transcriptomic analysis reveals the host factor VCAM-1 affecting porcine delta coronavirus infection.

Title:
Transcriptomic analysis reveals the host factor VCAM-1 affecting porcine delta coronavirus infection.
Authors:
Wei J; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China., Li Z; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China; Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China., Li S; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China; Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China., Xing Y; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China; Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China., Wang F; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China; Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China., Jin X; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China; Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China. Electronic address: jinxiaohui2020@126.com., Wei Z; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China; Longhu Laboratory of Henan Province, Zhengzhou 450046, PR China; Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, PR China. Electronic address: weizhanyongcn@henau.edu.com.
Source:
Veterinary microbiology [Vet Microbiol] 2026 Feb; Vol. 313, pp. 110873. Date of Electronic Publication: 2026 Jan 03.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Elsevier Scientific Pub. Co Country of Publication: Netherlands NLM ID: 7705469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2542 (Electronic) Linking ISSN: 03781135 NLM ISO Abbreviation: Vet Microbiol Subsets: MEDLINE
Imprint Name(s):
Original Publication: Amsterdam, Elsevier Scientific Pub. Co.
MeSH Terms:
Swine Diseases*/virology , Swine Diseases*/genetics , Vascular Cell Adhesion Molecule-1*/genetics , Vascular Cell Adhesion Molecule-1*/metabolism , Coronavirus Infections*/veterinary , Coronavirus Infections*/virology , Coronavirus Infections*/genetics , Deltacoronavirus*/physiology , Transcriptome*, Animals ; Swine ; Gene Expression Profiling/veterinary
Contributed Indexing:
Keywords: Porcine deltacoronavirus; Transcriptome analysis; VCAM-1
Substance Nomenclature:
0 (Vascular Cell Adhesion Molecule-1)
Entry Date(s):
Date Created: 20260110 Date Completed: 20260121 Latest Revision: 20260121
Update Code:
20260130
DOI:
10.1016/j.vetmic.2026.110873
PMID:
41519055
Database:
MEDLINE

*Further Information*

*Porcine deltacoronavirus (PDCoV) is an emerging porcine coronavirus that causes acute watery diarrhea mainly in piglets. However, the mechanism of PDCoV infection is unclear, which hinders the development of new effective drugs and vaccines. In this study, host factors that involved in PDCoV infection were screened using RNA sequencing (RNA-seq) based transcriptome analysis. Adhesion molecule, vascular cell adhesion molecule 1 (VCAM-1), was selected from the differential genes. The expression of VCAM-1 was further verified by quantitative RT-PCR. It has also been validated in piglet challenge experiments. In the intestine mainly infected, VCAM-1 was detected to be significantly upregulated at the nucleic acid and protein levels. This indicates that VCAM-1 plays a role in the infection of PDCoV. These results help us to understand of the effects of PDCoV infection on host cells, providing a research basis for further screening of drug targets.
(Copyright © 2026. Published by Elsevier B.V.)*

*Declaration of Competing Interest The authors declare that they have no conflict of interest.*