*Result*: A hybrid stacked autoencoder and support vector machines-based expert system for heart failure detection.

Title:
A hybrid stacked autoencoder and support vector machines-based expert system for heart failure detection.
Authors:
Kamal MM; School of Electronic and Communication Engineering, Quanzhou University of Information Engineering, Quanzhou, 362000, China. mianmuhammadkamal@qzuie.edu.cn., Khan W; Department of Electrical Engineering, University of Science and Technology Bannu, Bannu, Pakistan., Shambour QY; Department of Data Science and Artificial Intelligence, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan., Gafar MA; Faculty of Medicine (FOM), Cairo University, Giza, Egypt., Alarifi A; Computer Science and Engineering Department, College of Applied Studies, Riyadh, 11437, Saudi Arabia., Sheraz M; Centre for Smart Systems and Automation, CoE for Robotics and Sensing Technologies, Faculty of Artificial Intelligence and Engineering, Cyberjaya, 63100, Selangor, Malaysia., Chuah TC; Centre for Smart Systems and Automation, CoE for Robotics and Sensing Technologies, Faculty of Artificial Intelligence and Engineering, Cyberjaya, 63100, Selangor, Malaysia. tcchuah@mmu.edu.my.
Source:
Scientific reports [Sci Rep] 2026 Jan 08; Vol. 16 (1), pp. 3886. Date of Electronic Publication: 2026 Jan 08.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
References:
Sci Rep. 2025 Mar 31;15(1):10971. (PMID: 40164615)
Biomed Res Int. 2020 Apr 27;2020:9816142. (PMID: 32420387)
Diagnostics (Basel). 2023 Nov 10;13(22):. (PMID: 37998558)
Comput Methods Programs Biomed. 2009 Feb;93(2):185-91. (PMID: 18951649)
IEEE Trans Inf Technol Biomed. 2009 Jul;13(4):621-8. (PMID: 19369167)
Biomedicines. 2023 Sep 01;11(9):. (PMID: 37760882)
Grant Information:
ORF-2025-1476 King Saud University; MMUI/250008 Multimedia University; RDTC/241149 Telekom Research and Development Sdn Bhd
Contributed Indexing:
Keywords: [Formula: see text] penalized support vector machine; Heart failure detection; Regularization; Stacked autoencoder
Entry Date(s):
Date Created: 20260108 Date Completed: 20260128 Latest Revision: 20260131
Update Code:
20260131
PubMed Central ID:
PMC12852871
DOI:
10.1038/s41598-025-34430-4
PMID:
41507422
Database:
MEDLINE

*Further Information*

*Heart failure (HF) detection is a critical task in medical diagnostics, often requiring accurate and efficient methods. This paper introduces a novel hybrid three stage expert system designed to improve HF detection. The proposed system integrates stacked autoencoder (AE) for feature extraction, an [Formula: see text]-penalized support vector machine (SVM) to select high quality subset of features from the autoencoded features, and a non-linear SVM for classification. The stacked AE extracts meaningful features from a set of HF risk factors, while the [Formula: see text]-SVM refines the feature set by selecting the most relevant features. In the final stage, a non-linear SVM with RBF kernel is used to classify the refined feature subset. The system is validated using a benchmark HF dataset, and its performance is evaluated using various metrics, including accuracy, sensitivity, specificity, Matthews correlation coefficient (MCC), and area under the curve (AUC). Experimental results show that the proposed system achieves an accuracy of 97.78%, sensitivity of 97.56%, specificity of 97.96%, and an MCC value of 0.955, outperforming current state-of-the-art methods. The system's ability to achieve high performance with a reduced feature set highlights its efficiency. The proposed approach provides a robust solution for HF detection, offering valuable decision support for healthcare professionals.
(© 2026. The Author(s).)*

*Declarations. Competing interests: The authors declare no competing interests.*