• Altered Functional Specializat...

*Result*: Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment: Associations With Gene Expression, Neurotransmitter Receptor Distribution, and SVM-SHAP Classification

Title:
Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment: Associations With Gene Expression, Neurotransmitter Receptor Distribution, and SVM-SHAP Classification
Authors:
Ji Y; Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Wang YY; Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China., Wu XR; Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Source:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2026 Jan; Vol. 32 (1), pp. e70678.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
Imprint Name(s):
Original Publication: Oxford, UK : Wiley-Blackwell, c2008-
MeSH Terms:
Receptors, Neurotransmitter*/metabolism , Receptors, Neurotransmitter*/genetics , Retinal Detachment*/diagnostic imaging , Retinal Detachment*/genetics , Retinal Detachment*/metabolism , Retinal Detachment*/physiopathology , Brain*/metabolism , Brain*/diagnostic imaging , Support Vector Machine*, Neuroimaging/methods ; Multimodal Imaging/methods ; Humans ; Male ; Female ; Middle Aged ; Adult ; Machine Learning ; Transcriptome ; Magnetic Resonance Imaging ; Gene Expression ; Aged
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Grant Information:
82160207 the National Natural Science Foundation of China; 20202ACBL216008 the Key Projects of Jiangxi Youth Science Fund; 202130156 the Science and Technology Plan of the Jiangxi Provincial Health and Health Commission
Contributed Indexing:
Keywords: Allen Human Brain Atlas; Shapley additive explanations; autonomy index; connectivity between functionally homotopic voxels; neurotransmitters receptors; rhegmatogenous retinal detachment; support vector machine
Substance Nomenclature:
0 (Receptors, Neurotransmitter)
Entry Date(s):
Date Created: 20260107 Date Completed: 20260107 Latest Revision: 20260207
Update Code:
20260207
PubMed Central ID:
PMC12775831
DOI:
10.1002/cns.70678
PMID:
41496659
Database:
MEDLINE

*Further Information*

*Background: Previous studies have reported functional alterations in the brains of patients with rhegmatogenous retinal detachment (RRD). However, it remains largely unclear whether RRD affects hemispheric specialization and interhemispheric coordination, and how these alterations relate to underlying gene expression patterns and neurotransmitter receptor distributions.
Methods: We employed the Autonomy Index (AI) and Connectivity between Functionally Homotopic Voxels (CFH) to quantify alterations in hemispheric specialization and interhemispheric cooperation in patients with RRD. Transcriptome-neuroimaging spatial correlation analysis was performed by integrating gene expression data from the Allen Human Brain Atlas (AHBA) to identify genes associated with AI and CFH alterations. Enrichment and protein-protein interaction analyses were conducted to characterize the biological processes and molecular features of these genes. Furthermore, we explored the spatial associations between AI/CFH abnormalities and neurotransmitter receptor distributions. Finally, a support vector machine (SVM) classifier combined with Shapley additive explanations (SHAP) was implemented to distinguish RRD patients from healthy controls (HCs) and to determine the most discriminative brain regions.
Results: RRD patients exhibited significant alterations in AI and CFH within the frontal lobe, occipital lobe, and thalamus. Transcriptome-neuroimaging integration revealed gene sets closely associated with these abnormalities. These genes were primarily enriched in key biological processes including synaptic signaling, sensory organ development, Notch signaling, and structural neuroplasticity. The spatial pattern of CFH changes showed strong alignment with the regional distributions of multiple neurotransmitter systems, particularly serotonergic, dopaminergic, glutamatergic, and cholinergic pathways. Finally, the SVM-SHAP classification framework identified CFH in the right thalamus as the most discriminative feature for differentiating RRD patients from HCs.
Conclusion: These findings deepen our neurobiological understanding of RRD-induced brain functional remodeling and provide theoretical support and a methodological foundation for developing central intervention strategies and potential discriminative imaging tools for retinal diseases.
(© 2026 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)*