Treffer: Cascades of effectiveness of next-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions.
Title:
Cascades of effectiveness of next-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions.
Authors:
Champagne C; Swiss Tropical and Public Health Institute, Allschwil, Switzerland. clara.champagne@swisstph.ch.; University of Basel, Basel, Switzerland. clara.champagne@swisstph.ch., Lemant J; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Assenga A; Ifakara Health Institute, Bagamoyo, Tanzania., Kibondo UA; Ifakara Health Institute, Bagamoyo, Tanzania., Lekundayo RG; Ifakara Health Institute, Bagamoyo, Tanzania., Mbuba E; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland.; Ifakara Health Institute, Bagamoyo, Tanzania., Moore J; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland.; Ifakara Health Institute, Bagamoyo, Tanzania., Muganga JB; Ifakara Health Institute, Bagamoyo, Tanzania., Ntabaliba WS; Ifakara Health Institute, Bagamoyo, Tanzania., Odufuwa OG; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland.; Ifakara Health Institute, Bagamoyo, Tanzania., Swai JK; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland.; Ifakara Health Institute, Bagamoyo, Tanzania., Alexa M; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Goers R; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Golumbeanu M; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Chitnis N; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Ross A; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., N'Guessan R; London School of Hygiene and Tropical Medicine, Department of Disease Control, London, UK.; Vector Control Product Evaluation Centre, Institut Pierre Richet, Bouaké, Côte d'Ivoire., Moore S; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland.; Ifakara Health Institute, Bagamoyo, Tanzania., Pothin E; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland.; Clinton Health Access Initiative, Boston, MA, USA.
Source:
Nature communications [Nat Commun] 2025 Dec 16; Vol. 16 (1), pp. 11162. Date of Electronic Publication: 2025 Dec 16.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Imprint Name(s):
Original Publication: [London] : Nature Pub. Group
MeSH Terms:
Malaria*/prevention & control , Malaria*/transmission , Mosquito Control*/methods , Insecticides*/pharmacology , Anopheles*/drug effects , Insecticide-Treated Bednets*, Mosquito Vectors/drug effects ; Pyrethrins/pharmacology ; Animals ; Humans ; Tanzania ; Models, Theoretical ; Insecticide Resistance
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Grant Information:
INV-030449 United States GATES Gates Foundation; INV-068864 Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation); INV-025569 United States GATES Gates Foundation
Substance Nomenclature:
0 (Insecticides)
0 (Pyrethrins)
0 (Pyrethrins)
Entry Date(s):
Date Created: 20251216 Date Completed: 20251216 Latest Revision: 20251221
Update Code:
20260130
PubMed Central ID:
PMC12708653
DOI:
10.1038/s41467-025-66130-y
PMID:
41402259
Database:
MEDLINE
Weitere Informationen
As insecticide resistance spreads in Africa, next-generation insecticide-treated nets (ITNs) are increasingly being deployed to protect vulnerable populations against malaria. While these nets provide greater entomological efficacy against resistant mosquitoes, their effectiveness against malaria transmission also depends on other factors, such as durability, access, usage, and activity patterns of hosts and vectors. Here, we quantify the impact of two next-generation ITNs, namely Interceptor®G2 (chlorfenapyr-pyrethroid) and Olyset® Plus (piperonyl butoxide-pyrethroid), in a cascade from entomological efficacy to population-level effectiveness. We use a mathematical model that we parameterize with entomological data and validate against results from randomized controlled trials. We found that, beyond entomological factors, operational factors including functional survival, ITN use and in-bed exposure critically impact ITN effectiveness overall and per ITN types. Our results obtained for Tanzania can be extended to other contexts in a dashboard allowing users to explore product selection based on setting-specific factors that influence ITN effectiveness.
(© 2025. The Author(s).)
Competing interests: A.A., U.A.K., R.G.L., E.M., J.M., J.B.M., W.S.N., O.G.O., J.K.S. and S.J.M. test vector control products for a range of manufacturers. The other authors declare no competing interests.