*Result*: Vitamin D and Oral Cancer.
Title:
Vitamin D and Oral Cancer.
Authors:
Mumena CH; The Copperbelt University, School of Medicine, Department of Dental Clinical Sciences, Ndola, Zambia. Chrispinus.mumena@cbu.ac.zm.; The Gothenburg University, Sahlgrenska Academy, Institute of Clinical Sciences, Oncology, Gothenburg, Sweden. Chrispinus.mumena@cbu.ac.zm., Akimbekov NS; International Center for Islamic Science and Innovation, Al-Farabi Kazakh National University, Almaty, Kazakhstan.; Scientific-Practical Center, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.; Ecology Research Institute, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkistan, Kazakhstan., Sasi R; The Copperbelt University, School of Medicine, Department of Dental Clinical Sciences, Ndola, Zambia., Mlawa M; The Copperbelt University, School of Medicine, Department of Dental Clinical Sciences, Ndola, Zambia., Mudhihiri MH; The Copperbelt University, School of Medicine, Department of Dental Clinical Sciences, Ndola, Zambia.
Source:
Advances in experimental medicine and biology [Adv Exp Med Biol] 2026; Vol. 1493, pp. 115-126.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0121103 Publication Model: Print Cited Medium: Print ISSN: 0065-2598 (Print) Linking ISSN: 00652598 NLM ISO Abbreviation: Adv Exp Med Biol Subsets: MEDLINE
Imprint Name(s):
Publication: 1998- : New York : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press.
Original Publication: New York, Plenum Press.
MeSH Terms:
Mouth Neoplasms*/pathology , Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/metabolism , Mouth Neoplasms*/genetics , Vitamin D*/therapeutic use , Vitamin D*/metabolism , Carcinoma, Squamous Cell*/pathology , Carcinoma, Squamous Cell*/drug therapy , Carcinoma, Squamous Cell*/metabolism , Carcinoma, Squamous Cell*/genetics , Vitamin D Deficiency*/metabolism , Vitamin D Deficiency*/genetics , Vitamin D Deficiency*/complications , Vitamin D Deficiency*/drug therapy, Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Humans ; Prognosis
References:
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR (2020) Head and neck squamous cell carcinoma. Nat Rev Dis Prim 6:92. https://doi.org/10.1038/s41572-020-00224-3. (PMID: 10.1038/s41572-020-00224-333243986)
Fanidi A, Muller DC, Midttun Ø, Ueland PM, Vollset SE, Relton C, Vineis P, Weiderpass E, Skeie G, Brustad M, Palli D, Tumino R, Grioni S, Sacerdote C, Bueno-De-Mesquita HB, Peeters PH, Boutron-Ruault MC, Kvaskoff M, Cadeau C, Huerta JM, Sánchez MJ, Agudo A, Lasheras C, Quirós JR, Chamosa S, Riboli E, Travis RC, Ward H, Murphy N, Khaw KT, Trichopoulou A, Lagiou P, Papatesta EM, Boeing H, Kuehn T, Katzke V, Steffen A, Johansson A, Brennan P, Johansson M (2016) Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Sci Rep 6:1–11. https://doi.org/10.1038/srep36017. (PMID: 10.1038/srep36017)
Anwar N, Pervez S, Chundriger Q, Awan S, Moatter T, Ali TS (2020) Oral cancer: clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan. PLoS One 15:1–15. https://doi.org/10.1371/journal.pone.0236359. (PMID: 10.1371/journal.pone.0236359)
Mehrotra R, Yadav S (2006) Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations. Indian J Cancer 43:60–66. https://doi.org/10.4103/0019-509X.25886. (PMID: 10.4103/0019-509X.2588616790942)
Taghavi N, Yazdi I (2015) Prognostic factors of survival rate in oral squamous cell carcinoma: clinical, histologic, genetic and molecular concepts. Arch Iran Med 18:314–319. (PMID: 25959914)
Ellington TD, Henley SJ, Senkomago V, O’Neil ME, Wilson RJ, Singh S, Thomas CC, Wu M, Richardson LC (2020) Trends in incidence of cancers of the oral cavity and pharynx-United States 2007-2016. MMWR Morb Mortal Wkly Rep 69:433–438. https://www.cdc.gov/cancer/dataviz. (PMID: 10.15585/mmwr.mm6915a1322982447755056)
Grimm M, Cetindis M, Biegner T, Lehman M, Munz A, Teriete P, Reinert S (2015) Serum vitamin D levels of patients with oral squamous cell carcinoma (OSCC) and expression of vitamin D receptor in oral precancerous lesions and OSCC. Med Oral Patol Oral Cir Bucal 20:e188–e195. https://doi.org/10.4317/medoral.20368. (PMID: 10.4317/medoral.20368256625564393981)
Pu Y, Zhu G, Xu Y, Zheng S, Tang B, Huang H, Wu IXY, Huang D, Liu Y, Zhang X (2021) Association between vitamin D exposure and head and neck cancer: a systematic review with meta-analysis. Front Immunol 12:1–11. https://doi.org/10.3389/fimmu.2021.627226. (PMID: 10.3389/fimmu.2021.627226)
Kingsley K, Bergman C, Keiserman M, Mobley C (2013) Oral cancer risk and vitamin D status, intake and supplementation: a review critical review oral cancer risk and vitamin D status, intake and – supplementation: a review. Open Access Cancer 1:1–5. https://digitalscholarship.unlv.edu/dental_fac_articles/52.
Baniebrahimi G, Mir F, Khanmohammadi R (2020) Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches. Cancer Cell Int 20:1–15. https://doi.org/10.1186/s12935-020-01192-0. (PMID: 10.1186/s12935-020-01192-0)
Anand A, Singh S, Sonkar AA, Husain N, Singh KR, Singh S, Kushwaha JK (2017) Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment. Wspolczesna Onkol 21:145–151. https://doi.org/10.5114/wo.2017.68623. (PMID: 10.5114/wo.2017.68623)
Udeabor SE, Albejadi AM, Al-Shehri WAK, Onwuka CI, Al-Fathani SY, Al Nazeh AA, Aldhahri SF, Alshahrani FA (2020) Serum levels of 25-hydroxy-vitamin D in patients with oral squamous cell carcinoma: making a case for chemoprevention. Clin Exp Dent Res 6:428–432. https://doi.org/10.1002/cre2.294. (PMID: 10.1002/cre2.294322467477453769)
Hama T, Norizoe C, Suga H, Mimura T, Kato T, Moriyama H, Urashima M (2011) Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. PLoS One 6:8–13. https://doi.org/10.1371/journal.pone.0029634. (PMID: 10.1371/journal.pone.0029634)
Carlberg C, Muñoz A (2022) An update on vitamin D signaling and cancer. Semin Cancer Biol 79:217–230. https://doi.org/10.1016/j.semcancer.2020.05.018. (PMID: 10.1016/j.semcancer.2020.05.01832485310)
Dou R, Ng K, Giovannucci EL, Manson JE, Qian ZR, Ogino S (2016) Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. Br J Nutr 115:1643–1660. https://doi.org/10.1017/S0007114516000696. (PMID: 10.1017/S0007114516000696272451044890569)
Beatrice JE (2015) Anticancer effects of vitamins. Am J Hematol Oncol 11:26–36. https://www.gotoper.com/publications/ajho/2015/2015oct/anticancer-effects-of-vitamin-d.
Khammissa RAG, Fourie J, Motswaledi MH, Ballyram R, Lemmer J, Feller L (2018) The biological activities of vitamin D and its receptor in relation to calcium and bone homeostasis, cancer, immune and cardiovascular systems, skin biology, and oral health. Biomed Res Int 2018:9276380. https://doi.org/10.1155/2018/9276380. (PMID: 10.1155/2018/9276380299515495987305)
Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G (2015) Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev 96:365–408. https://doi.org/10.1152/physrev.00014.2015. (PMID: 10.1152/physrev.00014.20154839493)
Vuolo L, Di Somma C, Faggiano A, Colao A (2012) Vitamin D and cancer. Front Endocrinol (Lausanne) 3:1–13. https://doi.org/10.3389/fendo.2012.00058. (PMID: 10.3389/fendo.2012.00058)
International Agency for Research on Cancer (2010) Vitamin D and cancer. In: Bioactive foods and extracts: cancer treatment and prevention. CRC Press, Boca Raton, pp 481–495. https://doi.org/10.1201/b10330. (PMID: 10.1201/b10330)
Imran S, Shah A (2020) Beneficial role of vitamin d in common cancers: is the evidence compelling enough? WCRJ 7:1–9. https://doi.org/10.32113/wcrj_20205_1574. (PMID: 10.32113/wcrj_20205_1574)
Bochen F, Balensiefer B, Körner S, Bittenbring JT, Neumann F, Koch A, Bumm K, Marx A, Wemmert S, Papaspyrou G, Zuschlag D, Kühn JP, Al Kadah B, Schick B, Linxweiler M (2018) Vitamin D deficiency in head and neck cancer patients–prevalence, prognostic value and impact on immune function. Onco Targets Ther 7:1–10. https://doi.org/10.1080/2162402X.2018.1476817. (PMID: 10.1080/2162402X.2018.1476817)
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF (2006) The role of vitamin D in cancer prevention. Am J Public Health 96:252–261. https://doi.org/10.2105/AJPH.2004.045260. (PMID: 10.2105/AJPH.2004.045260163805761470481)
Holick MF (2004) Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 79:362–371. https://doi.org/10.1093/ajcn/79.3.362. (PMID: 10.1093/ajcn/79.3.36214985208)
Akimbekov NS, Ortoski RA, Razzaque MS (2020) Effects of sunlight exposure and vitamin D supplementation on HIV patients. J Steroid Biochem Mol Biol 200:105664. https://doi.org/10.1016/j.jsbmb.2020.105664. (PMID: 10.1016/j.jsbmb.2020.10566432229174)
Mumena CH, Mudhihiri MH, Sasi R, Mlawa M, Nyerembe S, Akimbekov NS, Razzaque MS (2021) The relevance of vitamin D in the oral health of HIV infected patients. J Steroid Biochem Mol Biol 211:105905. https://doi.org/10.1016/j.jsbmb.2021.105905. (PMID: 10.1016/j.jsbmb.2021.10590533962013)
Mechanisms M, Implications T (2020) Vitamin D signaling in inflammation and cancer: molecular mechanisms and therapeutic implications. Molecules 25:1–31. https://doi.org/10.3390/molecules25143219. (PMID: 10.3390/molecules25143219)
Negri M, Gentile A, de Angelis C, Montò T, Patalano R, Colao A, Pivonello R, Pivonello C (2020) Vitamin D-induced molecular mechanisms to potentiate cancer therapy and to reverse drug-resistance in cancer cells. Nutrients 12:1–25. https://doi.org/10.3390/nu12061798. (PMID: 10.3390/nu12061798)
Campbell MJ, Trump DL (2017) Vitamin D receptor signaling and cancer. Endocrinol Metab Clin N Am 46:1009–1038. https://doi.org/10.1016/j.ecl.2017.07.007. (PMID: 10.1016/j.ecl.2017.07.007)
Kingsley K, Bergman C, Keiserman M, Mobley C (2013) Oral cancer risk and vitamin D status, intake and supplementation: a review. Open Access Cancer 1:1–5. https://doi.org/10.13172/2053-3918-1-1-545. (PMID: 10.13172/2053-3918-1-1-545)
Mäkitie A, Tuokkola I, Laurell G, Mäkitie O, Olsen K, Takes RP, Florek E, Szyfter K, Sier CFM, Ferlito A (2021) Vitamin D in head and neck cancer: a systematic review. Curr Oncol Rep 23:5. https://doi.org/10.1007/s11912-020-00996-7. (PMID: 10.1007/s11912-020-00996-7)
Walia C, Roy S (2020) The emerging role of vitamin D in oral epithelial pathology: a review. J Dent Oral Disord Ther 8:1–7. www.symbiosisonline.org , www.symbiosisonlinepublishing.com.
Jin T, Guo Y, Huang Z, Zhang Q, Huang Z, Zhang Y, Huang Z (2020) Vitamin D inhibits the proliferation of Oral Squamous Cell Carcinoma by suppressing lncRNA LUCAT1 through the MAPK pathway. J Cancer 11:5971–5981. https://doi.org/10.7150/jca.45389. (PMID: 10.7150/jca.45389329225387477417)
Frejborg E, Salo T, Salem A (2020) Role of cyclooxygenase-2 in head and neck tumorigenesis. Int J Mol Sci 21:1–17. https://doi.org/10.3390/ijms21239246. (PMID: 10.3390/ijms21239246)
Li TJ, Cui J (2013) COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma. Asian Pac J Trop Med 6:640–643. https://doi.org/10.1016/S1995-7645(13)60110-8. (PMID: 10.1016/S1995-7645(13)60110-823790336)
López-Verdín S, Martínez-Fierro MDLL, Garza-Veloz II, Zamora-Perez A, Grajeda-Cruz J, González-González R, Molina-Frechero N, Arocena-Sutz M, Bologna-Molina R (2019) E-Cadherin gene expression in oral cancer: clinical and prospective data. Med Oral Patol Oral Cir Bucal 24:e444–e451. https://doi.org/10.4317/medoral.23029. (PMID: 10.4317/medoral.23029312561886667017)
Santosh A, Jones T, Harvey J (2016) A review on oral cancer biomarkers: understanding the past and learning from the present. J Cancer Res Ther 12:486–492. https://doi.org/10.4103/0973-1482.176414. (PMID: 10.4103/0973-1482.17641427461598)
Fanidi A, Muller DC, Midttun Ø, Ueland PM, Vollset SE, Relton C, Vineis P, Weiderpass E, Skeie G, Brustad M, Palli D, Tumino R, Grioni S, Sacerdote C, Bueno-De-Mesquita HB, Peeters PH, Boutron-Ruault MC, Kvaskoff M, Cadeau C, Huerta JM, Sánchez MJ, Agudo A, Lasheras C, Quirós JR, Chamosa S, Riboli E, Travis RC, Ward H, Murphy N, Khaw KT, Trichopoulou A, Lagiou P, Papatesta EM, Boeing H, Kuehn T, Katzke V, Steffen A, Johansson A, Brennan P, Johansson M (2016) Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Sci Rep 6:1–11. https://doi.org/10.1038/srep36017. (PMID: 10.1038/srep36017)
Anwar N, Pervez S, Chundriger Q, Awan S, Moatter T, Ali TS (2020) Oral cancer: clinicopathological features and associated risk factors in a high risk population presenting to a major tertiary care center in Pakistan. PLoS One 15:1–15. https://doi.org/10.1371/journal.pone.0236359. (PMID: 10.1371/journal.pone.0236359)
Mehrotra R, Yadav S (2006) Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations. Indian J Cancer 43:60–66. https://doi.org/10.4103/0019-509X.25886. (PMID: 10.4103/0019-509X.2588616790942)
Taghavi N, Yazdi I (2015) Prognostic factors of survival rate in oral squamous cell carcinoma: clinical, histologic, genetic and molecular concepts. Arch Iran Med 18:314–319. (PMID: 25959914)
Ellington TD, Henley SJ, Senkomago V, O’Neil ME, Wilson RJ, Singh S, Thomas CC, Wu M, Richardson LC (2020) Trends in incidence of cancers of the oral cavity and pharynx-United States 2007-2016. MMWR Morb Mortal Wkly Rep 69:433–438. https://www.cdc.gov/cancer/dataviz. (PMID: 10.15585/mmwr.mm6915a1322982447755056)
Grimm M, Cetindis M, Biegner T, Lehman M, Munz A, Teriete P, Reinert S (2015) Serum vitamin D levels of patients with oral squamous cell carcinoma (OSCC) and expression of vitamin D receptor in oral precancerous lesions and OSCC. Med Oral Patol Oral Cir Bucal 20:e188–e195. https://doi.org/10.4317/medoral.20368. (PMID: 10.4317/medoral.20368256625564393981)
Pu Y, Zhu G, Xu Y, Zheng S, Tang B, Huang H, Wu IXY, Huang D, Liu Y, Zhang X (2021) Association between vitamin D exposure and head and neck cancer: a systematic review with meta-analysis. Front Immunol 12:1–11. https://doi.org/10.3389/fimmu.2021.627226. (PMID: 10.3389/fimmu.2021.627226)
Kingsley K, Bergman C, Keiserman M, Mobley C (2013) Oral cancer risk and vitamin D status, intake and supplementation: a review critical review oral cancer risk and vitamin D status, intake and – supplementation: a review. Open Access Cancer 1:1–5. https://digitalscholarship.unlv.edu/dental_fac_articles/52.
Baniebrahimi G, Mir F, Khanmohammadi R (2020) Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches. Cancer Cell Int 20:1–15. https://doi.org/10.1186/s12935-020-01192-0. (PMID: 10.1186/s12935-020-01192-0)
Anand A, Singh S, Sonkar AA, Husain N, Singh KR, Singh S, Kushwaha JK (2017) Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment. Wspolczesna Onkol 21:145–151. https://doi.org/10.5114/wo.2017.68623. (PMID: 10.5114/wo.2017.68623)
Udeabor SE, Albejadi AM, Al-Shehri WAK, Onwuka CI, Al-Fathani SY, Al Nazeh AA, Aldhahri SF, Alshahrani FA (2020) Serum levels of 25-hydroxy-vitamin D in patients with oral squamous cell carcinoma: making a case for chemoprevention. Clin Exp Dent Res 6:428–432. https://doi.org/10.1002/cre2.294. (PMID: 10.1002/cre2.294322467477453769)
Hama T, Norizoe C, Suga H, Mimura T, Kato T, Moriyama H, Urashima M (2011) Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. PLoS One 6:8–13. https://doi.org/10.1371/journal.pone.0029634. (PMID: 10.1371/journal.pone.0029634)
Carlberg C, Muñoz A (2022) An update on vitamin D signaling and cancer. Semin Cancer Biol 79:217–230. https://doi.org/10.1016/j.semcancer.2020.05.018. (PMID: 10.1016/j.semcancer.2020.05.01832485310)
Dou R, Ng K, Giovannucci EL, Manson JE, Qian ZR, Ogino S (2016) Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. Br J Nutr 115:1643–1660. https://doi.org/10.1017/S0007114516000696. (PMID: 10.1017/S0007114516000696272451044890569)
Beatrice JE (2015) Anticancer effects of vitamins. Am J Hematol Oncol 11:26–36. https://www.gotoper.com/publications/ajho/2015/2015oct/anticancer-effects-of-vitamin-d.
Khammissa RAG, Fourie J, Motswaledi MH, Ballyram R, Lemmer J, Feller L (2018) The biological activities of vitamin D and its receptor in relation to calcium and bone homeostasis, cancer, immune and cardiovascular systems, skin biology, and oral health. Biomed Res Int 2018:9276380. https://doi.org/10.1155/2018/9276380. (PMID: 10.1155/2018/9276380299515495987305)
Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G (2015) Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev 96:365–408. https://doi.org/10.1152/physrev.00014.2015. (PMID: 10.1152/physrev.00014.20154839493)
Vuolo L, Di Somma C, Faggiano A, Colao A (2012) Vitamin D and cancer. Front Endocrinol (Lausanne) 3:1–13. https://doi.org/10.3389/fendo.2012.00058. (PMID: 10.3389/fendo.2012.00058)
International Agency for Research on Cancer (2010) Vitamin D and cancer. In: Bioactive foods and extracts: cancer treatment and prevention. CRC Press, Boca Raton, pp 481–495. https://doi.org/10.1201/b10330. (PMID: 10.1201/b10330)
Imran S, Shah A (2020) Beneficial role of vitamin d in common cancers: is the evidence compelling enough? WCRJ 7:1–9. https://doi.org/10.32113/wcrj_20205_1574. (PMID: 10.32113/wcrj_20205_1574)
Bochen F, Balensiefer B, Körner S, Bittenbring JT, Neumann F, Koch A, Bumm K, Marx A, Wemmert S, Papaspyrou G, Zuschlag D, Kühn JP, Al Kadah B, Schick B, Linxweiler M (2018) Vitamin D deficiency in head and neck cancer patients–prevalence, prognostic value and impact on immune function. Onco Targets Ther 7:1–10. https://doi.org/10.1080/2162402X.2018.1476817. (PMID: 10.1080/2162402X.2018.1476817)
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF (2006) The role of vitamin D in cancer prevention. Am J Public Health 96:252–261. https://doi.org/10.2105/AJPH.2004.045260. (PMID: 10.2105/AJPH.2004.045260163805761470481)
Holick MF (2004) Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 79:362–371. https://doi.org/10.1093/ajcn/79.3.362. (PMID: 10.1093/ajcn/79.3.36214985208)
Akimbekov NS, Ortoski RA, Razzaque MS (2020) Effects of sunlight exposure and vitamin D supplementation on HIV patients. J Steroid Biochem Mol Biol 200:105664. https://doi.org/10.1016/j.jsbmb.2020.105664. (PMID: 10.1016/j.jsbmb.2020.10566432229174)
Mumena CH, Mudhihiri MH, Sasi R, Mlawa M, Nyerembe S, Akimbekov NS, Razzaque MS (2021) The relevance of vitamin D in the oral health of HIV infected patients. J Steroid Biochem Mol Biol 211:105905. https://doi.org/10.1016/j.jsbmb.2021.105905. (PMID: 10.1016/j.jsbmb.2021.10590533962013)
Mechanisms M, Implications T (2020) Vitamin D signaling in inflammation and cancer: molecular mechanisms and therapeutic implications. Molecules 25:1–31. https://doi.org/10.3390/molecules25143219. (PMID: 10.3390/molecules25143219)
Negri M, Gentile A, de Angelis C, Montò T, Patalano R, Colao A, Pivonello R, Pivonello C (2020) Vitamin D-induced molecular mechanisms to potentiate cancer therapy and to reverse drug-resistance in cancer cells. Nutrients 12:1–25. https://doi.org/10.3390/nu12061798. (PMID: 10.3390/nu12061798)
Campbell MJ, Trump DL (2017) Vitamin D receptor signaling and cancer. Endocrinol Metab Clin N Am 46:1009–1038. https://doi.org/10.1016/j.ecl.2017.07.007. (PMID: 10.1016/j.ecl.2017.07.007)
Kingsley K, Bergman C, Keiserman M, Mobley C (2013) Oral cancer risk and vitamin D status, intake and supplementation: a review. Open Access Cancer 1:1–5. https://doi.org/10.13172/2053-3918-1-1-545. (PMID: 10.13172/2053-3918-1-1-545)
Mäkitie A, Tuokkola I, Laurell G, Mäkitie O, Olsen K, Takes RP, Florek E, Szyfter K, Sier CFM, Ferlito A (2021) Vitamin D in head and neck cancer: a systematic review. Curr Oncol Rep 23:5. https://doi.org/10.1007/s11912-020-00996-7. (PMID: 10.1007/s11912-020-00996-7)
Walia C, Roy S (2020) The emerging role of vitamin D in oral epithelial pathology: a review. J Dent Oral Disord Ther 8:1–7. www.symbiosisonline.org , www.symbiosisonlinepublishing.com.
Jin T, Guo Y, Huang Z, Zhang Q, Huang Z, Zhang Y, Huang Z (2020) Vitamin D inhibits the proliferation of Oral Squamous Cell Carcinoma by suppressing lncRNA LUCAT1 through the MAPK pathway. J Cancer 11:5971–5981. https://doi.org/10.7150/jca.45389. (PMID: 10.7150/jca.45389329225387477417)
Frejborg E, Salo T, Salem A (2020) Role of cyclooxygenase-2 in head and neck tumorigenesis. Int J Mol Sci 21:1–17. https://doi.org/10.3390/ijms21239246. (PMID: 10.3390/ijms21239246)
Li TJ, Cui J (2013) COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma. Asian Pac J Trop Med 6:640–643. https://doi.org/10.1016/S1995-7645(13)60110-8. (PMID: 10.1016/S1995-7645(13)60110-823790336)
López-Verdín S, Martínez-Fierro MDLL, Garza-Veloz II, Zamora-Perez A, Grajeda-Cruz J, González-González R, Molina-Frechero N, Arocena-Sutz M, Bologna-Molina R (2019) E-Cadherin gene expression in oral cancer: clinical and prospective data. Med Oral Patol Oral Cir Bucal 24:e444–e451. https://doi.org/10.4317/medoral.23029. (PMID: 10.4317/medoral.23029312561886667017)
Santosh A, Jones T, Harvey J (2016) A review on oral cancer biomarkers: understanding the past and learning from the present. J Cancer Res Ther 12:486–492. https://doi.org/10.4103/0973-1482.176414. (PMID: 10.4103/0973-1482.17641427461598)
Contributed Indexing:
Keywords: Apoptosis; Complement factor D; Humans; Mouth neoplasms; Prognosis; Quality of life; Regulated cell death; Vitamin D; Vitamin D deficiency
Substance Nomenclature:
1406-16-2 (Vitamin D)
0 (Receptors, Calcitriol)
0 (Receptors, Calcitriol)
Entry Date(s):
Date Created: 20251111 Date Completed: 20251113 Latest Revision: 20251113
Update Code:
20260130
DOI:
10.1007/978-3-032-04357-3_9
PMID:
41219602
Database:
MEDLINE
*Further Information*
*Oral cancer has high mortality and recurrence rates. This is attributed to resistance to the process of regulated cell death and resistance to radiotherapy and chemotherapy. Oral squamous cell carcinoma (OSCC) accounts for the majority of oral cancers. Its prognosis varies with the site, clinical stage, and histological grade of the tumor. Owing to the variation in the biological behavior of OSCC, the existing prognostic parameters have some limitations in terms of providing precise information on prognosis. The remarkable biological effects of vitamin D against oral cancer have been documented in various studies. These include antiproliferative and anti-invasive effects, inhibition of angiogenesis, stimulation of mutual adherence of cells, and induction of apoptosis in OSCC. Furthermore, vitamin D increases the sensitivity of OSCC tumor cells to chemotherapy. This phenomenon has been observed in tumors that are resistant to chemotherapy. These findings indicate that the biological effects of vitamin D may provide significant prognostic value in oral cancer patients. In addition, the administration of vitamin D improves the quality of life of patients with inoperable oral cancer lesions in addition to the reported increase in tumor sensitivity to chemotherapy. A low level of vitamin D is associated with increased oral cancer risk. A high frequency of vitamin D deficiency and pleomorphism of the VDR have been reported in oral cancer patients. Poorly differentiated and aggressive OSCCs exhibit more CYP24A1 and VDR polymorphisms and less CYP27B1. Determination of the serum level of vitamin D and identification of VDR, CYP24A1, and CYP27B1 in oral cancer cells may be of significant prognostic value in oral cancer patients and may significantly improve the management of head and neck cancers.
(© 2026. The Author(s), under exclusive license to Springer Nature Switzerland AG.)*