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  • The grand escape - how pathoge...

Treffer: The grand escape - how pathogens outsmart the human complement system.

Title:
The grand escape - how pathogens outsmart the human complement system.
Authors:
Nowacka AA; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany., Sordo Vieira L; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of America., Petr V; Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic., Fageräng B; Department of Immunology, University of Oslo, and Oslo University Hospital, Oslo, Norway; Department of Clinical Immunology, Rigshospitalet, and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Würzner R; Institute of Hygiene & Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: reinhard.wuerzner@i-med.ac.at., Ohms M; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany. Electronic address: mareike.ohms@uksh.de.
Source:
Immunobiology [Immunobiology] 2025 Nov; Vol. 230 (6), pp. 153126. Date of Electronic Publication: 2025 Oct 24.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8002742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3279 (Electronic) Linking ISSN: 01712985 NLM ISO Abbreviation: Immunobiology Subsets: MEDLINE
Imprint Name(s):
Publication: <2005->: Amsterdam : Elsevier
Original Publication: Stuttgart ; New York, Fischer.
MeSH Terms:
Complement System Proteins*/immunology , Complement System Proteins*/metabolism , Host-Pathogen Interactions*/immunology , Immune Evasion*, Complement Activation/immunology ; Humans ; Animals
Grant Information:
K25 AI175668 United States AI NIAID NIH HHS; R01 HL169974 United States HL NHLBI NIH HHS
Contributed Indexing:
Keywords: Biomarkers; Complement; Immune evasion; Infection; Pathogen; Therapy
Substance Nomenclature:
9007-36-7 (Complement System Proteins)
Entry Date(s):
Date Created: 20251104 Date Completed: 20251215 Latest Revision: 20260306
Update Code:
20260306
DOI:
10.1016/j.imbio.2025.153126
PMID:
41187580
Database:
MEDLINE

Weitere Informationen

Infectious diseases remain a significant cause of mortality and morbidity worldwide. Complement is a critical component in the defense against pathogens and despite their great differences, viruses, bacteria, fungi, and protists have all developed similar mechanisms of evasion from the human complement system. Using examples from four microbial groups (viruses, bacteria, fungi and protists), this review expands on examples of these different mechanisms of evasion. The mechanisms are grouped as (A) avoidance of recognition, (B) avoidance of eradication, (C) avoidance of activation and function, or (D) use of the complement proteins for entry into the host, in accordance with the classification initially proposed in 1999. Furthermore, this review will expand on novel descriptions of complement evasion, for example involving intracellular complement. Taken toge complement evasion is an essential tool used by pathogens not only in a defensive manner, protecting the pathogen from the host, but can also employed in an aggressive manner to aid the invasion of the host. Understanding these mechanisms has already influenced diagnostic and therapeutic tools, including vaccine development, and a further expansion of evasion molecules as biomarkers, vaccines or targets for therapy appears likely in the future.
(Copyright © 2025 The Authors. Published by Elsevier GmbH.. All rights reserved.)

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.