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Treffer: Comparative transcriptomics reveal universal and compound-specific mechanisms of insecticide response in the mulberry looper (Phthonandria atrilineata).

Title:
Comparative transcriptomics reveal universal and compound-specific mechanisms of insecticide response in the mulberry looper (Phthonandria atrilineata).
Authors:
Guan D; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China., Qin Y; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China; College of Life Sciences, Guangxi Normal University, Guilin, Guangxi 541004, China., Song J; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China., Qin Y; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China., Zhang S; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China., Xin L; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China., Li X; Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology, Guangxi Collaborative Innovation Center of Modern Sericulture and Silk, Guangxi Colleges Universities Key Laboratory of Exploitation and Utilization of Microbial and Botanical Resources, School of Chemistry and Bioengineering, Hechi University, Hechi 546300, China. Electronic address: lxdong_627@163.com.
Source:
Genomics [Genomics] 2025 Nov; Vol. 117 (6), pp. 111121. Date of Electronic Publication: 2025 Sep 30.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Academic Press Country of Publication: United States NLM ID: 8800135 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8646 (Electronic) Linking ISSN: 08887543 NLM ISO Abbreviation: Genomics Subsets: MEDLINE
Imprint Name(s):
Original Publication: San Diego : Academic Press, [c1987-
MeSH Terms:
Insecticides*/pharmacology , Insecticides*/toxicity , Transcriptome*/drug effects , Moths*/genetics , Moths*/drug effects , Moths*/metabolism, Malathion/pharmacology ; Insecticide Resistance/genetics ; Larva/drug effects ; Larva/genetics ; Larva/metabolism ; Organophosphates/pharmacology ; Animals
Contributed Indexing:
Keywords: Detoxification; Insecticide toxicity; Phthonandria atrilineata; Synergistic effects; Transcriptomics; Xenobiotic stress response
Substance Nomenclature:
0 (Insecticides)
U5N7SU872W (Malathion)
0 (Organophosphates)
Entry Date(s):
Date Created: 20251002 Date Completed: 20251205 Latest Revision: 20251205
Update Code:
20260130
DOI:
10.1016/j.ygeno.2025.111121
PMID:
41038406
Database:
MEDLINE

Weitere Informationen

Understanding insect molecular responses to different insecticides is essential for sustainable pest management. This study presents a comprehensive transcriptomic analysis of Phthonandria atrilineata exposed to insecticides with distinct modes of action. RNA sequencing was performed on larvae treated with organophosphates (trichlorfon, malathion, and trichlorfon-malathion mixture) and mitochondrial inhibitors (methoxyfenozide and chlorfenapyr). Our analysis revealed both mechanism-specific responses and conserved xenobiotic defense programs. We identified 180 commonly upregulated genes involved in detoxification and sensory perception pathways, and 357 commonly downregulated genes indicating suppression of carbohydrate metabolism and developmental processes under chemical stress. Fuzzy clustering revealed nine distinct expression modules, with organophosphates primarily affecting neuronal functions while mitochondrial inhibitors triggered metabolic reprogramming centered on energy balance and protein homeostasis. Additionally, the trichlorfon-malathion mixture produced synergistic effects on endocrine signaling pathways. These findings illuminate the molecular architecture of insecticide responses, providing valuable insights for pest management strategies and resistance monitoring in agricultural settings.
(Copyright © 2024. Published by Elsevier Inc.)

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Xiao-Dong Li reports administrative support, article publishing charges, equipment, drugs, or supplies, and statistical analysis were provided by Hechi University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.