• Clinical and EEG characteristi...

*Result*: Clinical and EEG characteristics of sleep-related hypermotor epilepsy in children.

Title:
Clinical and EEG characteristics of sleep-related hypermotor epilepsy in children.
Authors:
Tan X; Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China., Liu H; Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China., Li Y; Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China., Hu Q; Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China., Yan L; Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China., Chen J; Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. Electronic address: 290171621@qq.com., Hong S; Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China., Jiang L; Department of Neurology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China.
Source:
Epilepsy research [Epilepsy Res] 2025 Dec; Vol. 218, pp. 107664. Date of Electronic Publication: 2025 Sep 12.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8703089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6844 (Electronic) Linking ISSN: 09201211 NLM ISO Abbreviation: Epilepsy Res Subsets: MEDLINE
Imprint Name(s):
Original Publication: Amsterdam : Elsevier Science Publishers, c1987-
MeSH Terms:
Sleep*/physiology , Epilepsy, Partial, Motor*/physiopathology, Drug Resistant Epilepsy/physiopathology ; Drug Resistant Epilepsy/surgery ; Humans ; Electroencephalography ; Male ; Child ; Female ; Child, Preschool ; Adolescent ; Retrospective Studies ; Infant
Contributed Indexing:
Keywords: Electroencephalography; Etiology; Nocturnal frontal lobe epilepsy; Semiology; Sleep-related hypermotor epilepsy
Entry Date(s):
Date Created: 20250917 Date Completed: 20251126 Latest Revision: 20251201
Update Code:
20260130
DOI:
10.1016/j.eplepsyres.2025.107664
PMID:
40961515
Database:
MEDLINE

*Further Information*

*Background: Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy with nocturnal hypermotor seizures. Although SHE was redefined in 2014, comprehensive pediatric studies are still lacking for this disorder. To address this need, here we describe the clinical and electroencephalography (EEG) characteristics of children with SHE.
Methods: We retrospectively enrolled pediatric patients with SHE diagnosis who were hospitalized at our institution from August 1, 2021, to August 31, 2023.
Results: Among the 47 patients, 31.9 % and 42.6 % manifested as SP2 and SP3, respectively. A total of 57.4 % of the patients showed a focal discharge as diagnosed by interictal EEG, 36.2 % showed multifocal discharges, and 6.4 % did not have discharge. Ictal EEG revealed that 66.0 % of patients presented with frontal lobe onset, 10.6 % with temporal lobe onset, and 23.4 % with unknown onset. Further, 36.2 % of patients had a structural etiology, approximately 80 % of those patients had focal cortical dysplasia. Finally, 23 patients were diagnosed with refractory epilepsy, and 15 of them underwent surgery.
Conclusions: Patients mainly presented as SP3 and SP2. The focal discharges detected by interictal EEG accounted for approximately 57.4 % and the frontal lobe onset detected by ictal EEG accounted for approximately 66 %. Structural etiology (mainly focal cortical dysplasia) accounted for approximately 33 %, and surgery was an effective treatment for these patients.
(Copyright © 2025 Elsevier B.V. All rights reserved.)*

*Declaration of Competing Interest The authors declare no competing financial interests or personal relationships that could be perceived as affecting the work reported in this paper.*