• Fabrication of Patterned Compo...

*Result*: Fabrication of Patterned Composite Microneedles via Inkjet Printing for Enhanced Drug Delivery.

Title:
Fabrication of Patterned Composite Microneedles via Inkjet Printing for Enhanced Drug Delivery.
Authors:
Jang S; Department of Smart Health Science and Technology, Kangwon National University (KNU), 1, Kangwondaehak-gil, Chuncheon-si, Gangwon-do, Republic of Korea., Lee J; Department of Smart Health Science and Technology, Kangwon National University (KNU), 1, Kangwondaehak-gil, Chuncheon-si, Gangwon-do, Republic of Korea., Lee H; Department of Smart Health Science and Technology, Kangwon National University (KNU), 1, Kangwondaehak-gil, Chuncheon-si, Gangwon-do, Republic of Korea.; Department of Mechanical and Biomedical, Mechatronics Engineering, Kangwon National University (KNU), 1, Kangwondaehak-gil, Chuncheon-si, Gangwon-do, Republic of Korea.
Source:
Advanced healthcare materials [Adv Healthc Mater] 2026 Jan; Vol. 15 (1), pp. e02291. Date of Electronic Publication: 2025 Sep 04.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101581613 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2192-2659 (Electronic) Linking ISSN: 21922640 NLM ISO Abbreviation: Adv Healthc Mater Subsets: MEDLINE
Imprint Name(s):
Original Publication: Weinheim : Wiley-VCH, 2012-
MeSH Terms:
Drug Delivery Systems*/methods , Drug Delivery Systems*/instrumentation , Needles* , Printing*, Gelatin/chemistry ; Hydrogels/chemistry ; Methacrylates/chemistry ; Animals ; Printing, Three-Dimensional ; Drug Liberation
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Grant Information:
National Research Foundation of Korea; RS-2024-00423107 Korean government (MSIT); Korea Health Industry Development Institute (KHIDI); Ministry of Health & Welfare, Republic of Korea; RS-2025-24535069 Republic of Korea Korea Health Industry Development Institute
Contributed Indexing:
Keywords: customization; inkjet printing; microneedle patches; wound healing
Substance Nomenclature:
9000-70-8 (Gelatin)
0 (Hydrogels)
0 (gelatin methacryloyl)
0 (Methacrylates)
Entry Date(s):
Date Created: 20250904 Date Completed: 20260110 Latest Revision: 20260112
Update Code:
20260130
PubMed Central ID:
PMC12790304
DOI:
10.1002/adhm.202502291
PMID:
40904238
Database:
MEDLINE

*Further Information*

*Microneedle (MN) technology offers a minimally invasive, patient-friendly alternative to conventional hypodermic injections for dermal drug delivery. However, traditional micro-molding techniques are limited by single-material fabrication, involving labor-intensive processes, excessive material waste, and scalability issues, restricting broader therapeutic applications. To address these challenges, an inkjet printing method is implemented to fabricate multi-material MN patches using gelatin and gelatin methacryloyl (GelMA) hydrogels. This technique enables precise control over hydrogel composition, allowing for MN patches with tailored mechanical strength, multi-drug incorporation, and functional enhancements achieved by integrating different materials. By tailoring gelation processes for each hydrogel type, MN structures can be customized to meet specific therapeutic needs, such as enhanced mechanical integrity or rapid dissolution for targeted drug release. Unlike conventional micro-molding, the method eliminates complex post-processing steps like centrifugation and vacuum treatment, reducing material waste and production time. Furthermore, the inkjet printing method facilitates multi-drug incorporation within a single MN patch, expanding its potential for targeted, multi-drug delivery applications. Drug delivery studies validated the efficacy of these multi-material MN patches, highlighting the potential of inkjet printing as a scalable, efficient, and cost-effective platform for advanced transdermal drug delivery systems.
(© 2025 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)*