• Unlocking the anti-aging poten...

Treffer: Unlocking the anti-aging potential: In silico analysis of astaxanthin, curcumin, quercetin, and resveratrol in modulating skin aging pathways.

Title:
Unlocking the anti-aging potential: In silico analysis of astaxanthin, curcumin, quercetin, and resveratrol in modulating skin aging pathways.
Authors:
Barbosa DG; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil., Barbosa KRM; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil., Guaitolini YM; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil., Casotti MC; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil., da Cruz RGC; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil., Altoé LSC; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil., Pavan IP; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil; State University of Rio de Janeiro (UERJ), Roberto Alcântara Gomes Biology Institute (IBRAG), Rio de Janeiro, Rio de Janeiro, Brazil., de Carvalho EF; State University of Rio de Janeiro (UERJ), Roberto Alcântara Gomes Biology Institute (IBRAG), Rio de Janeiro, Rio de Janeiro, Brazil., Louro ID; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil., Meira DD; Federal University of Espírito Santo (UFES), Department of Biological Sciences, Vitoria, Espirito Santo, Brazil. Electronic address: debora.meira@ufes.br.
Source:
Computational biology and chemistry [Comput Biol Chem] 2026 Feb; Vol. 120 (Pt 1), pp. 108633. Date of Electronic Publication: 2025 Aug 19.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-928X (Electronic) Linking ISSN: 14769271 NLM ISO Abbreviation: Comput Biol Chem Subsets: MEDLINE
Imprint Name(s):
Publication: Oxford : Elsevier
Original Publication: Oxford : Pergamon, c2003-
MeSH Terms:
Resveratrol*/pharmacology , Resveratrol*/chemistry , Skin Aging*/drug effects , Curcumin*/pharmacology , Curcumin*/chemistry , Quercetin*/pharmacology , Quercetin*/chemistry , Computer Simulation* , Antioxidants*/pharmacology , Antioxidants*/chemistry, Humans ; Xanthophylls/pharmacology ; Xanthophylls/chemistry ; Protein Interaction Maps/drug effects
Contributed Indexing:
Keywords: Aging; Bioinformatics; Cosmetology; Inflammation; Natural Products; Systems Biology
Substance Nomenclature:
Q369O8926L (Resveratrol)
8XPW32PR7I (astaxanthine)
IT942ZTH98 (Curcumin)
9IKM0I5T1E (Quercetin)
0 (Xanthophylls)
0 (Antioxidants)
Entry Date(s):
Date Created: 20250824 Date Completed: 20251210 Latest Revision: 20251210
Update Code:
20260130
DOI:
10.1016/j.compbiolchem.2025.108633
PMID:
40850171
Database:
MEDLINE

Weitere Informationen

Multiple studies have linked aging to a result of the inflammatory response. Thus, there is a recognized need for cosmeceuticals that modulate inflammation pathways to prevent and treat aging. In this sense, four bioactive compounds were selected for their documented anti-inflammatory/antioxidant properties. Therefore, this study aimed to evaluate whether the bioactive compounds astaxanthin, curcumin, quercetin, and resveratrol are effective in treating the effects of skin aging, using in silico analyses. Protein-protein interaction networks (PPINs) related to skin aging and the bioactive compounds astaxanthin, curcumin, quercetin, and resveratrol were generated using the Cytoscape plug-in to analyze the functional enrichment of recovered proteins. From these main networks, clusters and bottleneck networks were generated. Initially, 5 main PPINs were generated. From the clusters recovered from the main networks, 3 were selected from the general network and 11 from the specific networks. Through functional enrichment of the clusters, the biological process of response to oxidative stress was identified. Blood and blood-forming tissue, vascular, and immune system abnormality phenotypes were also observed, along with an increase in inflammatory response. Additionally, Reactome pathways related to interleukin signaling and detoxification of reactive oxygen species were noted. Finally, the key genes for each network were identified from the bottleneck networks: IL-6 (general and astaxanthin), TAB1 (curcumin), TNF-α (quercetin), and TP53 (resveratrol). Based on this research, the analyzed bioactive compounds suggest potential efficacy to be included in cosmetic products, as they are capable of reducing excessive oxidative stress and inflammatory processes, consequently preventing cellular aging.
(Copyright © 2025 Elsevier Ltd. All rights reserved.)

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.