*Result*: RNA interference (RNAi) for insect pest management: understanding mechanisms, strategies, challenges and future prospects.
Title:
RNA interference (RNAi) for insect pest management: understanding mechanisms, strategies, challenges and future prospects.
Authors:
Mahanta DK; Forest Entomology Discipline, Forest Protection Division, Indian Council of Forestry Research and Education (ICFRE)-Forest Research Institute (ICFRE-FRI), Dehradun, Uttarakhand, 248006, India., Komal J; Basic Tasar Silkworm Seed Organization, Pendari, 495 112, Bilaspur, India, Bilaspur, Chhattisgarh, 495 112, India., Bhoi TK; Forest Protection Division, ICFRE-Arid Forest Research Institute (ICFRE-AFRI), Jodhpur, Rajasthan, India. bhoitanmaya152@gmail.com., Samal I; ICAR-National Research Centre on Litchi, Mushahari, Ramna, Muzaffarpur, Bihar, India. happyipsu29@gmail.com., Dash S; ICAR-Indian Agricultural Reserach Institute, New Delhi, India., Jangra S; UF/IFAS Tropical Research and Education Centre, Homestead, Florida, USA.
Source:
Biologia futura [Biol Futur] 2025 Dec; Vol. 76 (4), pp. 465-477. Date of Electronic Publication: 2025 Aug 19.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101738236 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2676-8607 (Electronic) Linking ISSN: 26768607 NLM ISO Abbreviation: Biol Futur Subsets: MEDLINE
Imprint Name(s):
Publication: 2020- : [Cham, Switzerland] : [Budapest] : Springer International Publishing ; Akadémiai Kiadó
Original Publication: [Budapest] : Akadémiai Kiadó, [2019]-
Original Publication: [Budapest] : Akadémiai Kiadó, [2019]-
MeSH Terms:
References:
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Contributed Indexing:
Keywords: Insect; Management; Pest; RNAi; dsRNA
Entry Date(s):
Date Created: 20250819 Date Completed: 20251124 Latest Revision: 20251124
Update Code:
20260130
DOI:
10.1007/s42977-025-00281-3
PMID:
40830542
Database:
MEDLINE
*Further Information*
*RNA interference (RNAi) has emerged as a promising strategy for controlling insect pests, offering precise and environmentally sustainable alternatives to traditional pest control methods. By introducing double-stranded RNA (dsRNA) that specifically targets essential genes involved in pest survival, RNAi disrupts gene expression in target organisms. Various delivery methods, including topical application, transgenic plants, and nanoparticles, have been developed to enhance the effective administration of dsRNA. However, RNAi faces several challenges, including off-target effects, species-specific variations in efficacy, and the potential for resistance development. Despite these obstacles, ongoing research is focused on addressing these issues and improving the efficiency of RNAi-based pest control approaches. Future prospects for RNAi in insect pest management include advancements in delivery technologies, the identification of novel target genes, and the integration of RNAi with complementary pest control strategies. In conclusion, RNAi represents a potential long-term and targeted solution for insect pest control. Continued research and technological advancements are driving its adoption and expanding its application in agriculture and forestry globally. This review provides an in-depth analysis of RNAi mechanisms, evaluates current strategies, highlights the challenges faced, and explores the future directions for its use in insect pest management.
(© 2025. Akadémiai Kiadó Zrt.)*
*Declarations. Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Consent to participate: Not applicable. Consent for publication: Not applicable. Ethical approval: Not applicable.*