• A Comprehensive Research Disse...

*Result*: A Comprehensive Research Dissemination Model for Polymer-Based Neural Interfaces.

Title:
A Comprehensive Research Dissemination Model for Polymer-Based Neural Interfaces.
Authors:
Scholten K, Xu H, Lu Z, Jiang W, Jin Z, Ortigoza-Diaz J, Petrossians A, Orler S, Gallonio R, Liu X, Song D, Meng E
Source:
IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2026 Feb; Vol. 73 (2), pp. 934-944.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Institute Of Electrical And Electronics Engineers Country of Publication: United States NLM ID: 0012737 Publication Model: Print Cited Medium: Internet ISSN: 1558-2531 (Electronic) Linking ISSN: 00189294 NLM ISO Abbreviation: IEEE Trans Biomed Eng Subsets: MEDLINE
Imprint Name(s):
Publication: New York, NY : Institute Of Electrical And Electronics Engineers
Original Publication: New York, IEEE Professional Technical Group on Bio-Medical Engineering.
MeSH Terms:
Polymers*/chemistry , Electrodes, Implanted* , Brain-Computer Interfaces*, Electroencephalography/instrumentation ; Hippocampus/physiology ; Animals ; Rats ; Microelectrodes ; Equipment Design ; Rats, Sprague-Dawley
Comments:
Update of: bioRxiv. 2023 Nov 06:2023.11.05.565048. doi: 10.1101/2023.11.05.565048.. (PMID: 37986740)
Grant Information:
U24 NS113647 United States NS NINDS NIH HHS
Substance Nomenclature:
0 (Polymers)
Entry Date(s):
Date Created: 20250806 Date Completed: 20260121 Latest Revision: 20260122
Update Code:
20260130
DOI:
10.1109/TBME.2025.3596222
PMID:
40768444
Database:
MEDLINE

*Further Information*

*Objective: Implantable polymer microelectrode arrays (pMEAs) offer stable integration with neural tissue but are not widely available. An academic resource model is explored as a means of standardizing and disseminating pMEAs.
Methods: The resource is based on a multi-project wafer model, originally developed in the semiconductor industry, allowing the simultaneous microfabrication of pMEAs with arbitrary designs. This model leverages innovations in design, manufacturing, and packaging to produce custom penetrating, surface, and cuff-type form-factors in batch and at low cost. Device quality is verified through benchtop testing and chronic electrophysiological recording in rats.
Results: To date, over 1000 pMEAs (more than 50 designs) were provided to 45 academic labs. Implanted penetrating arrays in the hippocampus achieved high quality, chronic recordings from freely moving rats. Surface arrays reliably recorded electroencephalogram signals from the cortex and evoked potentials from the somatosensory cortex in awake rats.
Conclusion: Efficient production of custom pMEAs for research is possible through a unique resource model inspired by the semiconductor industry.
Significance: Greater access to pMEAs enables researchers to conduct new experiments across different regions of the nervous system, accelerating discoveries.*