*Result*: Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment.
Title:
Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment.
Authors:
Zhu X; Department of Anatomy and Neuroscience, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo-shi 693-8501, Shimane, Japan., Yu Y; Department of Anatomy and Neuroscience, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo-shi 693-8501, Shimane, Japan., Jiang Z; Department of Anatomy and Neuroscience, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo-shi 693-8501, Shimane, Japan., Otani Y; Department of Anatomy and Neuroscience, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo-shi 693-8501, Shimane, Japan., Fujitani M; Department of Anatomy and Neuroscience, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo-shi 693-8501, Shimane, Japan.
Source:
Biomolecules [Biomolecules] 2025 Jun 19; Vol. 15 (6). Date of Electronic Publication: 2025 Jun 19.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, 2011-
MeSH Terms:
References:
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Neuron. 2016 Feb 3;89(3):461-71. (PMID: 26844830)
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J Cell Biol. 1998 Nov 30;143(5):1295-304. (PMID: 9832557)
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Curr Opin Neurobiol. 2023 Jun;80:102697. (PMID: 36907075)
Ann N Y Acad Sci. 2018 May;1420(1):46-61. (PMID: 29749636)
Mol Psychiatry. 2020 Nov;25(11):2800-2817. (PMID: 30504823)
J Cell Biol. 1968 Jul;38(1):193-201. (PMID: 5691973)
J Cell Biol. 2007 Aug 27;178(5):875-86. (PMID: 17709431)
Nat Cell Biol. 2003 Jul;5(7):626-32. (PMID: 12819789)
Curr Opin Neurobiol. 2014 Jun;26:142-8. (PMID: 24556285)
J Clin Invest. 2010 Oct;120(10):3508-19. (PMID: 20877009)
J Neurosci. 2018 Feb 28;38(9):2135-2145. (PMID: 29378864)
Mol Cell Neurosci. 2008 Oct;39(2):180-92. (PMID: 18621130)
Neuron. 2017 May 17;94(4):809-825.e7. (PMID: 28521134)
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Front Cell Neurosci. 2016 Oct 25;10:250. (PMID: 27826229)
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Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4822-7. (PMID: 22411828)
Cell Rep. 2015 Dec 29;13(12):2781-93. (PMID: 26711344)
Neuron. 2019 Nov 6;104(3):458-470.e5. (PMID: 31542321)
J Biol Chem. 2003 Jul 25;278(30):27333-9. (PMID: 12716895)
Cell Mol Life Sci. 2013 Jan;70(1):105-20. (PMID: 22763697)
J Neurosci. 2016 Apr 20;36(16):4421-33. (PMID: 27098687)
EMBO J. 2017 May 2;36(9):1227-1242. (PMID: 28283581)
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1214-9. (PMID: 25552561)
J Cell Sci. 2017 Nov 1;130(21):3663-3675. (PMID: 28935671)
Annu Rev Neurosci. 2012;35:249-65. (PMID: 22443507)
Neuron. 2019 Oct 23;104(2):305-321.e8. (PMID: 31474508)
J Cell Biol. 1998 Sep 21;142(6):1571-81. (PMID: 9744885)
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J Cell Biol. 2008 Dec 15;183(6):1101-14. (PMID: 19064667)
Channels (Austin). 2022 Dec;16(1):216-229. (PMID: 36082411)
Science. 2003 Jun 27;300(5628):2091-4. (PMID: 12829783)
J Comp Neurol. 2015 Apr 1;523(5):814-30. (PMID: 25421039)
Mol Cell Neurosci. 2006 Dec;33(4):441-6. (PMID: 17045809)
J Neurosci. 2010 Jan 20;30(3):1038-48. (PMID: 20089912)
Biochemistry. 2008 Jul 15;47(28):7452-64. (PMID: 18563915)
Cell Rep. 2012 Dec 27;2(6):1546-53. (PMID: 23246006)
PLoS One. 2013 Aug 13;8(8):e73750. (PMID: 23967349)
Cell. 2004 Oct 15;119(2):257-72. (PMID: 15479642)
Proc Natl Acad Sci U S A. 2011 May 24;108(21):8826-31. (PMID: 21551097)
J Cell Biol. 1997 May 5;137(3):703-14. (PMID: 9151675)
Nat Neurosci. 2009 Aug;12(8):996-1002. (PMID: 19633666)
Nat Rev Neurosci. 2010 Aug;11(8):552-62. (PMID: 20631711)
Cell. 2012 May 25;149(5):1125-39. (PMID: 22632975)
BMC Biol. 2011 Sep 29;9:66. (PMID: 21958379)
J Biol Chem. 2001 Apr 6;276(14):10646-54. (PMID: 11152476)
J Neurosci. 2019 Jun 19;39(25):4864-4873. (PMID: 30967428)
J Neurosci. 2008 Jun 11;28(24):6111-7. (PMID: 18550753)
Proc Natl Acad Sci U S A. 2020 May 19;117(20):11097-11108. (PMID: 32358199)
J Cell Biol. 2024 Oct 7;223(10):. (PMID: 39078369)
Neuroscience. 2006;138(2):365-75. (PMID: 16427210)
BMC Neurosci. 2008 Nov 13;9:112. (PMID: 19014551)
J Comp Neurol. 2014 Aug 1;522(11):2594-608. (PMID: 24477962)
J Neurosci. 2006 Mar 8;26(10):2599-613. (PMID: 16525039)
Cereb Cortex. 2017 Sep 1;27(9):4662-4675. (PMID: 28922860)
J Neurosci. 1996 Nov 1;16(21):6839-52. (PMID: 8824323)
Sci Adv. 2025 May 23;11(21):eadv1281. (PMID: 40408471)
J Neurosci. 2024 Oct 16;44(42):. (PMID: 39251352)
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2965-9. (PMID: 8159688)
Front Cell Neurosci. 2017 Jan 10;10:304. (PMID: 28123356)
J Neurosci. 2017 Nov 22;37(47):11311-11322. (PMID: 29038240)
Nat Commun. 2020 Jan 3;11(1):100. (PMID: 31900387)
Mol Biol Cell. 2024 Jun 1;35(6):ar81. (PMID: 38598291)
Neuron. 2014 Oct 22;84(2):399-415. (PMID: 25374361)
J Biol Chem. 2015 Mar 13;290(11):6925-36. (PMID: 25616663)
J Neurochem. 2005 Sep;94(5):1243-53. (PMID: 15992371)
Dev Cell. 2014 Jan 27;28(2):117-31. (PMID: 24412576)
J Cell Biol. 2000 Nov 27;151(5):985-1002. (PMID: 11086001)
J Biol Chem. 2015 Jul 3;290(27):16619-32. (PMID: 25998125)
J Neurosci. 2008 May 28;28(22):5731-9. (PMID: 18509034)
J Neurosci. 2008 Dec 31;28(53):14329-40. (PMID: 19118165)
Science. 2013 Jan 25;339(6118):452-6. (PMID: 23239625)
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8870-5. (PMID: 16735477)
J Cell Biol. 1968 Dec;39(3):604-19. (PMID: 5699934)
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17564-9. (PMID: 19805144)
J Neurochem. 2015 Aug;134(3):527-37. (PMID: 25950943)
Brain Res. 1977 Nov 11;136(2):345-50. (PMID: 922488)
Mol Psychiatry. 2013 Aug;18(8):922-9. (PMID: 22850628)
J Cell Sci. 2019 Jan 16;132(2):. (PMID: 30598502)
Neuron. 2018 Feb 7;97(3):555-570.e6. (PMID: 29395909)
J Cell Biol. 2007 Feb 12;176(4):509-19. (PMID: 17283186)
Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1207-1215. (PMID: 31889000)
J Cell Biol. 2002 Jan 21;156(2):337-48. (PMID: 11807096)
Cereb Cortex. 2012 Jul;22(7):1648-61. (PMID: 21940706)
J Cell Biol. 2001 Nov 26;155(5):739-46. (PMID: 11724816)
Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2310120121. (PMID: 39058579)
Nat Neurosci. 2008 Feb;11(2):178-86. (PMID: 18204443)
Mol Cell Neurosci. 2018 Sep;91:131-139. (PMID: 29730177)
Neural Plast. 2016;2016:6808293. (PMID: 27493806)
Curr Top Membr. 2013;72:1-37. (PMID: 24210426)
Exp Mol Med. 2022 Jul;54(7):867-877. (PMID: 35794211)
J Neurosci. 2003 Mar 15;23(6):2306-13. (PMID: 12657689)
Nat Commun. 2023 Oct 26;14(1):6797. (PMID: 37884508)
Cells. 2021 Aug 17;10(8):. (PMID: 34440880)
J Cell Biol. 1997 Jun 16;137(6):1355-67. (PMID: 9182667)
iScience. 2020 May 22;23(5):101053. (PMID: 32344377)
J Cell Sci. 2001 Nov;114(Pt 21):3823-35. (PMID: 11719549)
EMBO J. 2002 Dec 2;21(23):6387-96. (PMID: 12456646)
Neuron. 2015 Dec 16;88(6):1208-1226. (PMID: 26671463)
Physiol Rev. 2025 Apr 01;105(2):765-801. (PMID: 39480263)
Neuron. 2013 May 8;78(3):469-82. (PMID: 23664614)
Neuron. 2016 Feb 3;89(3):461-71. (PMID: 26844830)
Neuron. 2014 Jun 4;82(5):1058-73. (PMID: 24908486)
J Cell Biol. 1998 Nov 30;143(5):1295-304. (PMID: 9832557)
Cell Mol Life Sci. 2022 Oct 29;79(11):575. (PMID: 36309617)
Front Cell Neurosci. 2016 Mar 01;10:39. (PMID: 26973458)
Front Mol Neurosci. 2024 May 10;17:1376997. (PMID: 38799616)
Cells. 2023 Apr 21;12(8):. (PMID: 37190119)
Cell Rep. 2019 Aug 27;28(9):2413-2426.e7. (PMID: 31461655)
Nat Commun. 2023 Dec 11;14(1):8201. (PMID: 38081810)
J Physiol. 2011 Oct 15;589(Pt 20):4959-80. (PMID: 21825022)
Curr Opin Neurobiol. 2023 Jun;80:102697. (PMID: 36907075)
Ann N Y Acad Sci. 2018 May;1420(1):46-61. (PMID: 29749636)
Mol Psychiatry. 2020 Nov;25(11):2800-2817. (PMID: 30504823)
J Cell Biol. 1968 Jul;38(1):193-201. (PMID: 5691973)
J Cell Biol. 2007 Aug 27;178(5):875-86. (PMID: 17709431)
Nat Cell Biol. 2003 Jul;5(7):626-32. (PMID: 12819789)
Curr Opin Neurobiol. 2014 Jun;26:142-8. (PMID: 24556285)
J Clin Invest. 2010 Oct;120(10):3508-19. (PMID: 20877009)
J Neurosci. 2018 Feb 28;38(9):2135-2145. (PMID: 29378864)
Mol Cell Neurosci. 2008 Oct;39(2):180-92. (PMID: 18621130)
Neuron. 2017 May 17;94(4):809-825.e7. (PMID: 28521134)
Neuron. 2025 Mar 05;113(5):649-669. (PMID: 39947181)
Front Cell Neurosci. 2016 Oct 25;10:250. (PMID: 27826229)
Front Cell Neurosci. 2019 May 28;13:234. (PMID: 31191255)
J Neurosci. 2013 Apr 3;33(14):6191-202. (PMID: 23554500)
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4822-7. (PMID: 22411828)
Cell Rep. 2015 Dec 29;13(12):2781-93. (PMID: 26711344)
Neuron. 2019 Nov 6;104(3):458-470.e5. (PMID: 31542321)
J Biol Chem. 2003 Jul 25;278(30):27333-9. (PMID: 12716895)
Cell Mol Life Sci. 2013 Jan;70(1):105-20. (PMID: 22763697)
J Neurosci. 2016 Apr 20;36(16):4421-33. (PMID: 27098687)
EMBO J. 2017 May 2;36(9):1227-1242. (PMID: 28283581)
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1214-9. (PMID: 25552561)
J Cell Sci. 2017 Nov 1;130(21):3663-3675. (PMID: 28935671)
Annu Rev Neurosci. 2012;35:249-65. (PMID: 22443507)
Neuron. 2019 Oct 23;104(2):305-321.e8. (PMID: 31474508)
J Cell Biol. 1998 Sep 21;142(6):1571-81. (PMID: 9744885)
J Cell Sci. 2017 Jul 1;130(13):2209-2220. (PMID: 28533267)
J Cell Biol. 2008 Dec 15;183(6):1101-14. (PMID: 19064667)
Channels (Austin). 2022 Dec;16(1):216-229. (PMID: 36082411)
Science. 2003 Jun 27;300(5628):2091-4. (PMID: 12829783)
Grant Information:
23K07290 Japan Society for the Promotion of Science
Contributed Indexing:
Keywords: Ankyrin-G; axon initial segment; binding partners; proteome
Substance Nomenclature:
0 (Ankyrins)
Entry Date(s):
Date Created: 20250626 Date Completed: 20250626 Latest Revision: 20250628
Update Code:
20260130
PubMed Central ID:
PMC12190637
DOI:
10.3390/biom15060901
PMID:
40563541
Database:
MEDLINE
*Further Information*
*The axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier. A key organizer of the AIS is Ankyrin-G, a scaffolding protein responsible for clustering voltage-gated ion channels, cell adhesion molecules (CAMs), and cytoskeletal components at this critical neuronal domain. Recent proteomic analyses have revealed a complex network of proteins in the AIS, emphasizing Ankyrin-G's central role in its molecular architecture. This review discusses new findings in the study of AIS-associated proteins. It explains how Ankyrin-G and its binding partners (such as ion channels, CAMs, spectrins, actin, and microtubule-associated proteins including end-binding protein 3, tripartite motif-containing protein 46, and calmodulin-regulated spectrin-associated protein 2) organize their structure. Understanding the dynamic regulation and molecular interactions within the AIS offers insights into neuronal excitability and reveals potential therapeutic targets for axonal dysfunction-related diseases. Through these dynamic interactions, Ankyrin-G ensures the proper alignment and dense clustering of key channel complexes, thereby maintaining the AIS's distinctive molecular and functional identity. By further unraveling the complexity of Ankyrin-G's interactome, our understanding of AIS formation, maintenance, and plasticity will be considerably enhanced, contributing to the elucidation of the pathogenesis of neurological and neuropsychiatric disorders.*