• Axon initial segment plasticit...

*Result*: Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.

Title:
Axon initial segment plasticity caused by auditory deprivation degrades time difference sensitivity in a model of neural responses to cochlear implants.
Authors:
Jing A; Department of Mathematics and Statistics, Swarthmore College, 500 College Ave, Swarthmore, PA, 19081, USA.; Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY, 10012-1185, USA., Xi S; Department of Mathematics and Statistics, Swarthmore College, 500 College Ave, Swarthmore, PA, 19081, USA., Fransazov I; Department of Mathematics and Statistics, Swarthmore College, 500 College Ave, Swarthmore, PA, 19081, USA., Goldwyn JH; Department of Mathematics and Statistics, Swarthmore College, 500 College Ave, Swarthmore, PA, 19081, USA. jhgoldwyn@gmail.com.
Source:
Journal of computational neuroscience [J Comput Neurosci] 2025 Jun; Vol. 53 (2), pp. 267-288. Date of Electronic Publication: 2025 Apr 17.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Springer US Country of Publication: United States NLM ID: 9439510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6873 (Electronic) Linking ISSN: 09295313 NLM ISO Abbreviation: J Comput Neurosci Subsets: MEDLINE
Imprint Name(s):
Publication: New York : Springer US
Original Publication: Boston : Kluwer Academic Publishers, 1994-
MeSH Terms:
Neuronal Plasticity*/physiology , Axon Initial Segment*/physiology , Neurons*/physiology , Sensory Deprivation*/physiology , Cochlear Implants* , Models, Neurological*, Action Potentials/physiology ; Superior Olivary Complex/physiology ; Sound Localization/physiology ; Animals ; Humans ; Time Factors
References:
Hear Res. 2009 Feb;248(1-2):15-30. (PMID: 19110049)
PLoS Comput Biol. 2019 Mar 4;15(3):e1006476. (PMID: 30830905)
J Neurosci. 2002 Dec 15;22(24):11019-25. (PMID: 12486197)
J Neurophysiol. 2014 Aug 15;112(4):802-13. (PMID: 24848460)
Nature. 2002 May 30;417(6888):543-7. (PMID: 12037566)
Front Neurosci. 2023 Jan 04;16:1021541. (PMID: 36685222)
Hear Res. 2001 Mar;153(1-2):64-79. (PMID: 11223297)
Hear Res. 2020 Nov;397:107976. (PMID: 32591097)
Nat Neurosci. 2010 May;13(5):601-9. (PMID: 20364143)
J Assoc Res Otolaryngol. 2001 Sep;2(3):216-32. (PMID: 11669395)
J Assoc Res Otolaryngol. 2007 Sep;8(3):356-72. (PMID: 17562109)
Ear Hear. 2008 Dec;29(6):819-29. (PMID: 18941413)
J Neurophysiol. 2007 May;97(5):3449-59. (PMID: 16914612)
Hear Res. 2015 Sep;327:126-35. (PMID: 26074305)
J Physiol. 2002 Apr 15;540(Pt 2):447-55. (PMID: 11956335)
Neuron. 2013 Jun 5;78(5):936-48. (PMID: 23764292)
J Assoc Res Otolaryngol. 2015 Feb;16(1):135-58. (PMID: 25348578)
J Acoust Soc Am. 2008 Feb;123(2):1030-42. (PMID: 18247905)
J Neurosci. 1996 Feb 1;16(3):993-1007. (PMID: 8558268)
Neuroscience. 2013 Sep 5;247:117-33. (PMID: 23707979)
J Neurosci. 2010 Dec 15;30(50):17111-21. (PMID: 21159981)
J Neurophysiol. 2011 Oct;106(4):1985-99. (PMID: 21775710)
Nat Commun. 2015 Nov 19;6:8815. (PMID: 26581625)
J Neurophysiol. 2004 Jun;91(6):2465-73. (PMID: 14749317)
J Assoc Res Otolaryngol. 2008 Mar;9(1):122-37. (PMID: 18204987)
Otol Neurotol. 2008 Jun;29(4):509-12. (PMID: 18520586)
Ear Hear. 2006 Dec;27(6):714-31. (PMID: 17086081)
Sci Rep. 2023 Mar 7;13(1):3785. (PMID: 36882473)
Hear Res. 2006 Apr;214(1-2):17-27. (PMID: 16520009)
J Neurosci. 2011 Jun 15;31(24):8936-47. (PMID: 21677177)
J Neurosci Methods. 2021 Jul 1;358:109212. (PMID: 33957156)
Neural Comput. 1998 Nov 15;10(8):1987-2017. (PMID: 9804669)
Nat Commun. 2014 May 07;5:3790. (PMID: 24804642)
J Acoust Soc Am. 2003 Mar;113(3):1617-30. (PMID: 12656396)
Ear Hear. 2007 Aug;28(4):524-41. (PMID: 17609614)
Front Neural Circuits. 2022 Apr 14;16:856926. (PMID: 35498371)
J Acoust Soc Am. 1999 Jul;106(1):281-90. (PMID: 10420622)
Nat Rev Neurosci. 2003 Jul;4(7):540-50. (PMID: 12838329)
J Physiol. 2012 Nov 15;590(22):5571-9. (PMID: 23027822)
Curr Opin Otolaryngol Head Neck Surg. 2007 Oct;15(5):315-8. (PMID: 17823546)
Eur J Neurosci. 2010 Nov;32(10):1658-67. (PMID: 20946234)
J Neurosci. 2014 Apr 9;34(15):5370-84. (PMID: 24719114)
PLoS Biol. 2010 Jun 29;8(6):e1000406. (PMID: 20613857)
Front Cell Neurosci. 2019 Oct 15;13:456. (PMID: 31680869)
J Neurophysiol. 2003 Jun;89(6):3097-113. (PMID: 12783953)
J Neurophysiol. 2012 Sep;108(5):1430-52. (PMID: 22673331)
J Neurophysiol. 1994 Mar;71(3):1022-36. (PMID: 8201399)
IEEE Trans Biomed Eng. 1999 Jun;46(6):617-29. (PMID: 10356868)
Eur J Neurosci. 2006 Aug;24(4):1137-46. (PMID: 16930439)
Nat Neurosci. 2015 Mar;18(3):444-52. (PMID: 25664914)
Physiol Rev. 2010 Jul;90(3):983-1012. (PMID: 20664077)
Trends Neurosci. 2003 Jul;26(7):347-50. (PMID: 12850430)
J Physiol. 2006 Apr 15;572(Pt 2):313-21. (PMID: 16469782)
J Neurosci. 2014 Feb 26;34(9):3443-53. (PMID: 24573300)
Nature. 1998 May 21;393(6682):268-72. (PMID: 9607764)
Nature. 2006 Dec 21;444(7122):1069-72. (PMID: 17136099)
Eur Arch Otorhinolaryngol. 2021 Dec;278(12):4671-4679. (PMID: 33388985)
JAMA Otolaryngol Head Neck Surg. 2013 Mar;139(3):265-72. (PMID: 23429927)
Hear Res. 2000 Aug;146(1-2):143-52. (PMID: 10913891)
Hear Res. 2010 Sep 1;268(1-2):93-104. (PMID: 20580801)
IEEE Trans Biomed Eng. 1999 Jun;46(6):630-7. (PMID: 10356869)
Nat Neurosci. 2002 Mar;5(3):247-53. (PMID: 11850629)
Hear Res. 2008 Aug;242(1-2):3-21. (PMID: 18616994)
Audiol Neurootol. 2004 Jul-Aug;9(4):234-46. (PMID: 15205551)
Hear Res. 2015 Apr;322:89-98. (PMID: 25528491)
Hear Res. 2018 Apr;361:121-137. (PMID: 29496363)
IEEE Trans Biomed Eng. 2014 Nov;61(11):2749-59. (PMID: 24893366)
Biol Cybern. 2023 Apr;117(1-2):143-162. (PMID: 37129628)
Discrete Contin Dyn Syst Ser A. 2012 Aug 1;32(8):2729-2757. (PMID: 23667306)
Front Comput Neurosci. 2017 Feb 02;11:3. (PMID: 28210218)
Neuron. 2013 Jun 5;78(5):923-35. (PMID: 23764291)
J Assoc Res Otolaryngol. 2009 Mar;10(1):91-110. (PMID: 18941838)
J Acoust Soc Am. 1989 Sep;86(3):989-1006. (PMID: 2794252)
Nature. 2010 Jun 24;465(7301):1075-8. (PMID: 20543825)
Front Cell Neurosci. 2016 Oct 25;10:250. (PMID: 27826229)
J Acoust Soc Am. 2013 Oct;134(4):2923-36. (PMID: 24116428)
Trends Amplif. 2010 Jun;14(2):84-95. (PMID: 20724356)
Grant Information:
1951436 Division of Mathematical Sciences
Contributed Indexing:
Keywords: Axon initial segment; Cochlear implant; Computer model; Medial superior olive; Plasticity; Sound localization
Entry Date(s):
Date Created: 20250417 Date Completed: 20250623 Latest Revision: 20250624
Update Code:
20260130
PubMed Central ID:
PMC12181223
DOI:
10.1007/s10827-025-00902-9
PMID:
40244473
Database:
MEDLINE

*Further Information*

*Synaptic and neural properties can change during periods of auditory deprivation. These changes may disrupt the computations that neurons perform. In the brainstem of chickens, auditory deprivation can lead to changes in the size and biophysics of the axon initial segment (AIS) of neurons in the sound source localization circuit. This is the phenomenon of axon initial segment (AIS) plasticity. Individuals who use cochlear implants (CIs) experience periods of hearing loss, and so we ask whether AIS plasticity in neurons of the medial superior olive (MSO), a key stage of sound location processing, would impact time difference sensitivity in the scenario of hearing with cochlear implants. The biophysical changes that we implement in our model of AIS plasticity include enlargement of the AIS and replacement of low-threshold potassium conductance with the more slowly-activated M-type potassium conductance. AIS plasticity has been observed to have a homeostatic effect with respect to excitability. In our model, AIS plasticity has the additional effect of converting MSO neurons from phasic firing type to tonic firing type. Phasic firing is known to have greater temporal sensitivity to coincident inputs. Consistent with this, we find AIS plasticity degrades time difference sensitivity in the auditory deprived MSO neuron model across a range of stimulus parameters. Our study illustrates a possible mechanism of cellular plasticity in a non-peripheral stage of neural processing that could impose barriers to sound source localization by bilateral cochlear implant users.
(© 2025. The Author(s).)*

*Declarations. Conflict of Interest: The authors declare no Conflict of interest. Ethical Approval: Not applicable. No experimental data was used.*