*Result*: Femoral bone growth predictions based on personalized multi-scale simulations: validation and sensitivity analysis of a mechanobiological model.
Title:
Femoral bone growth predictions based on personalized multi-scale simulations: validation and sensitivity analysis of a mechanobiological model.
Authors:
Koller W; Department of Biomechanics, Kinesiology and Computer Science in Sport, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. willi.koller@univie.ac.at.; Neuromechanics Research Group, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria. willi.koller@univie.ac.at.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, Austria. willi.koller@univie.ac.at., Svehlik M; Department of Orthopedics and Traumatology, Medical University of Graz, Graz, Austria., Wallnöfer E; Department of Biomechanics, Kinesiology and Computer Science in Sport, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria.; Neuromechanics Research Group, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria.; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, Austria., Kranzl A; Laboratory for Gait and Human Movements, Orthopaedic Hospital Speising, Vienna, Austria.; Vienna Bone and Growth Center, Vienna, Austria., Mindler G; Department of Pediatric Orthopaedics, Orthopaedic Hospital Speising, Vienna, Austria.; Vienna Bone and Growth Center, Vienna, Austria., Baca A; Department of Biomechanics, Kinesiology and Computer Science in Sport, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria., Kainz H; Department of Biomechanics, Kinesiology and Computer Science in Sport, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria.; Neuromechanics Research Group, Centre for Sport Science and University Sports, University of Vienna, Vienna, Austria.
Source:
Biomechanics and modeling in mechanobiology [Biomech Model Mechanobiol] 2025 Jun; Vol. 24 (3), pp. 879-894. Date of Electronic Publication: 2025 Apr 14.
Publication Type:
Journal Article; Validation Study
Language:
English
Journal Info:
Publisher: Springer Country of Publication: Germany NLM ID: 101135325 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1617-7940 (Electronic) Linking ISSN: 16177940 NLM ISO Abbreviation: Biomech Model Mechanobiol Subsets: MEDLINE
Imprint Name(s):
Original Publication: Berlin ; New York : Springer, c2002-
MeSH Terms:
Femur*/growth & development , Femur*/diagnostic imaging , Femur*/physiology , Bone Development*/physiology , Models, Biological* , Computer Simulation*, Humans ; Child ; Male ; Biomechanical Phenomena ; Female ; Magnetic Resonance Imaging ; Reproducibility of Results ; Linear Models ; Sensitivity and Specificity
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JAMA. 2001 Jul 11;286(2):188-95. (PMID: 11448282)
IEEE Trans Biomed Eng. 2016 Oct;63(10):2068-79. (PMID: 27392337)
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J Biomech. 2021 Feb 12;116:110186. (PMID: 33515872)
J Biomech Eng. 2012 Jan;134(1):011005. (PMID: 22482660)
Gait Posture. 2020 Oct;82:54-60. (PMID: 32892101)
Biomech Model Mechanobiol. 2017 Dec;16(6):1869-1883. (PMID: 28639152)
Gait Posture. 2024 Sep;113:158-166. (PMID: 38905850)
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J Appl Biomech. 2017 Oct 1;33(5):354-360. (PMID: 28290736)
Sci Rep. 2024 Feb 12;14(1):3567. (PMID: 38347085)
Ann Biomed Eng. 2004 Feb;32(2):297-305. (PMID: 15008378)
J Biomech. 2016 Jun 14;49(9):1613-1619. (PMID: 27063249)
J Orthop Res. 2015 Feb;33(2):155-62. (PMID: 25284013)
J Biomech Eng. 2001 Oct;123(5):381-90. (PMID: 11601721)
IEEE Trans Biomed Eng. 2022 Jul;69(7):2268-2275. (PMID: 34990350)
J Orthop Res. 2013 Aug;31(8):1172-9. (PMID: 23575923)
J Orthop Res. 1990 May;8(3):383-92. (PMID: 2324857)
Nature. 2000 Jun 8;405(6787):704-6. (PMID: 10864330)
J Orthop Res. 2023 Mar;41(3):570-582. (PMID: 35689506)
J Biomech. 2019 Mar 27;86:55-63. (PMID: 30739769)
PLoS One. 2023 Sep 26;18(9):e0291789. (PMID: 37751435)
Sci Rep. 2024 May 11;14(1):10808. (PMID: 38734763)
PLoS Comput Biol. 2020 Dec 28;16(12):e1008493. (PMID: 33370252)
Clin Biomech (Bristol). 2021 Jul;87:105405. (PMID: 34161909)
Arch Orthop Trauma Surg. 2016 Sep;136(9):1259-1264. (PMID: 27501703)
Annu Rev Biomed Eng. 2017 Jun 21;19:279-299. (PMID: 28633565)
J Orthop Res. 1999 Sep;17(5):646-53. (PMID: 10569472)
J Pediatr Orthop. 2009 Jan-Feb;29(1):73-9. (PMID: 19098651)
Med Eng Phys. 2021 Apr;90:83-91. (PMID: 33781483)
Acta Bioeng Biomech. 2012;14(1):93-106. (PMID: 22741593)
PLoS One. 2023 Oct 12;18(10):e0291458. (PMID: 37824447)
Microsc Res Tech. 1994 Aug 15;28(6):505-19. (PMID: 7949396)
Bone. 1996 Jan;18(1 Suppl):5S-10S. (PMID: 8717541)
Anat Rec. 2001 Apr 1;262(4):398-419. (PMID: 11275971)
J Am Acad Orthop Surg. 2018 Oct 1;26(19):e416-e425. (PMID: 30106763)
Gait Posture. 2016 Sep;49:426-430. (PMID: 27513740)
Sci Rep. 2022 Jul 7;12(1):9842. (PMID: 35798755)
IEEE Trans Biomed Eng. 2007 Nov;54(11):1940-50. (PMID: 18018689)
Comput Methods Biomech Biomed Engin. 2011 Mar;14(3):253-62. (PMID: 20229379)
J Comput Assist Tomogr. 2015 Jan-Feb;39(1):83-5. (PMID: 25354092)
Front Endocrinol (Lausanne). 2021 Sep 27;12:754084. (PMID: 34646241)
J Orthop Res. 1988;6(6):804-16. (PMID: 3171761)
J Orthop Res. 1988;6(2):215-22. (PMID: 3343627)
J Biomech. 2019 Jan 23;83:134-142. (PMID: 30527636)
Gait Posture. 2012 Apr;35(4):556-60. (PMID: 22206783)
J Biomech. 2019 Mar 27;86:167-174. (PMID: 30799079)
J Biomech Eng. 2001 Oct;123(5):403-9. (PMID: 11601724)
Magn Reson Imaging. 2012 Nov;30(9):1323-41. (PMID: 22770690)
J Biomech Eng. 2013 Feb;135(2):021014. (PMID: 23445059)
J Biomech. 2015 Feb 26;48(4):644-650. (PMID: 25595425)
Clin Orthop Relat Res. 1999 Jul;(364):194-204. (PMID: 10416409)
Comput Methods Biomech Biomed Engin. 2014;17(4):352-9. (PMID: 22587414)
JAMA. 2001 Jul 11;286(2):188-95. (PMID: 11448282)
IEEE Trans Biomed Eng. 2016 Oct;63(10):2068-79. (PMID: 27392337)
Ann Biomed Eng. 2004 Mar;32(3):447-57. (PMID: 15095819)
J Biomech. 2016 Jan 25;49(2):141-8. (PMID: 26776930)
J Biomech. 2021 Aug 26;125:110589. (PMID: 34218040)
J Biomech. 2021 Feb 12;116:110186. (PMID: 33515872)
J Biomech Eng. 2012 Jan;134(1):011005. (PMID: 22482660)
Gait Posture. 2020 Oct;82:54-60. (PMID: 32892101)
Biomech Model Mechanobiol. 2017 Dec;16(6):1869-1883. (PMID: 28639152)
Gait Posture. 2024 Sep;113:158-166. (PMID: 38905850)
Front Bioeng Biotechnol. 2023 Jun 21;11:1165963. (PMID: 37415789)
J Bone Joint Surg Am. 1973 Dec;55(8):1726-38. (PMID: 4804993)
Front Bioeng Biotechnol. 2023 Feb 24;11:1140527. (PMID: 36911204)
Gait Posture. 2012 Jul;36(3):467-70. (PMID: 22766044)
Proc Inst Mech Eng H. 2012 Feb;226(2):103-12. (PMID: 22468462)
J Biomech. 2013 Sep 27;46(14):2394-401. (PMID: 23948374)
J Biomech. 2023 May;152:111569. (PMID: 37058768)
PLoS One. 2020 Jul 23;15(7):e0235966. (PMID: 32702015)
J Appl Biomech. 2017 Oct 1;33(5):354-360. (PMID: 28290736)
Sci Rep. 2024 Feb 12;14(1):3567. (PMID: 38347085)
Ann Biomed Eng. 2004 Feb;32(2):297-305. (PMID: 15008378)
J Biomech. 2016 Jun 14;49(9):1613-1619. (PMID: 27063249)
J Orthop Res. 2015 Feb;33(2):155-62. (PMID: 25284013)
J Biomech Eng. 2001 Oct;123(5):381-90. (PMID: 11601721)
IEEE Trans Biomed Eng. 2022 Jul;69(7):2268-2275. (PMID: 34990350)
J Orthop Res. 2013 Aug;31(8):1172-9. (PMID: 23575923)
J Orthop Res. 1990 May;8(3):383-92. (PMID: 2324857)
Nature. 2000 Jun 8;405(6787):704-6. (PMID: 10864330)
J Orthop Res. 2023 Mar;41(3):570-582. (PMID: 35689506)
J Biomech. 2019 Mar 27;86:55-63. (PMID: 30739769)
PLoS One. 2023 Sep 26;18(9):e0291789. (PMID: 37751435)
Sci Rep. 2024 May 11;14(1):10808. (PMID: 38734763)
PLoS Comput Biol. 2020 Dec 28;16(12):e1008493. (PMID: 33370252)
Clin Biomech (Bristol). 2021 Jul;87:105405. (PMID: 34161909)
Arch Orthop Trauma Surg. 2016 Sep;136(9):1259-1264. (PMID: 27501703)
Annu Rev Biomed Eng. 2017 Jun 21;19:279-299. (PMID: 28633565)
J Orthop Res. 1999 Sep;17(5):646-53. (PMID: 10569472)
J Pediatr Orthop. 2009 Jan-Feb;29(1):73-9. (PMID: 19098651)
Med Eng Phys. 2021 Apr;90:83-91. (PMID: 33781483)
Acta Bioeng Biomech. 2012;14(1):93-106. (PMID: 22741593)
PLoS One. 2023 Oct 12;18(10):e0291458. (PMID: 37824447)
Contributed Indexing:
Keywords: Femoral bone growth; Finite element analysis; Mechanobiological model validation; Musculoskeletal modelling; Semi-automated growth predictions
Entry Date(s):
Date Created: 20250414 Date Completed: 20250612 Latest Revision: 20250615
Update Code:
20260130
PubMed Central ID:
PMC12162800
DOI:
10.1007/s10237-025-01942-x
PMID:
40227492
Database:
MEDLINE
*Further Information*
*Musculoskeletal function is pivotal to long-term health. However, various patient groups develop torsional deformities, leading to clinical, functional problems. Understanding the interplay between movement pattern, bone loading and growth is crucial for improving the functional mobility of these patients and preserving long-term health. Multi-scale simulations in combination with a mechanobiological bone growth model have been used to estimate bone loads and predict femoral growth trends based on cross-sectional data. The lack of longitudinal data in the previous studies hindered refinements of the mechanobiological model and validation of subject-specific growth predictions, thereby limiting clinical applications. This study aimed to validate the growth predictions using magnetic resonance images and motion capture data-collected longitudinally-from ten growing children. Additionally, a sensitivity analysis was conducted to refine model parameters. A linear regression model based on physical activity information, anthropometric data and predictions from the refined mechanobiological model explained 70% of femoral anteversion development. Notably, the direction of femoral development was accurately predicted in 18 out of 20 femurs, suggesting that growth predictions could help to revolutionize treatment strategies for torsional deformities.
(© 2025. The Author(s).)*
*Declarations. Conflict of interest: The authors declare no competing interests.*