Treffer: The Primary Cilia are Associated with the Axon Initial Segment in Neurons.
Title:
The Primary Cilia are Associated with the Axon Initial Segment in Neurons.
Authors:
Wang H; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, 100871, China., Li Y; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, 100871, China., Li X; Beijing Life Science Academy, Beijing, 102200, China., Sun Z; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, 100871, China., Yu F; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, 100871, China., Pashang A; Centre for Advanced Computational Solutions (C-fACS), AGLS faculty, Lincoln University, Canterbury, 7647, New Zealand., Kulasiri D; Centre for Advanced Computational Solutions (C-fACS), AGLS faculty, Lincoln University, Canterbury, 7647, New Zealand., Li HW; Department of Chemistry, The Chinese University of Hong Kong, Hong Kong, 999077, China., Chen H; Beijing Life Science Academy, Beijing, 102200, China., Hou H; Beijing Life Science Academy, Beijing, 102200, China., Zhang Y; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, 100871, China.
Source:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Mar; Vol. 12 (9), pp. e2407405. Date of Electronic Publication: 2025 Jan 13.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Imprint Name(s):
Original Publication: Weinheim : WILEY-VCH, [2014]-
MeSH Terms:
Cilia*/metabolism , Cilia*/physiology , Receptors, Somatostatin*/metabolism , Receptors, Somatostatin*/genetics , Neurons*/metabolism , Neurons*/physiology , Axon Initial Segment*/metabolism , Axon Initial Segment*/physiology , Axons*/metabolism, Signal Transduction/physiology ; Neuronal Plasticity/physiology ; Animals ; Mice
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Grant Information:
2022ZD0211800 Ministry of Science and Technology; L246003 Natural Science Foundation of Beijing Municipality; 2024100CB0090;2024100CB0220 Beijing Life Science Academy (BLSA) Fund; Qidong-SLS Innovation Fund; Yifu Life Science Fund
Contributed Indexing:
Keywords: 5‐HT6R; SSTR3; axon initial segment; ciliary GPCR; primary cilia
Substance Nomenclature:
0 (Receptors, Somatostatin)
0 (somatostatin receptor 3)
0 (somatostatin receptor 3)
Entry Date(s):
Date Created: 20250113 Date Completed: 20250501 Latest Revision: 20250521
Update Code:
20260130
PubMed Central ID:
PMC11884599
DOI:
10.1002/advs.202407405
PMID:
39804991
Database:
MEDLINE
Weitere Informationen
The primary cilia serve as pivotal mediators of environmental signals and play crucial roles in neuronal responses. Disruption of ciliary function has been implicated in neuronal circuit disorders and aberrant neuronal excitability. However, the precise mechanisms remain elusive. To study the link between the primary cilia and neuronal excitability, manipulation of somatostatin receptor 3 (SSTR3) is investigated, as an example of how alterations in ciliary signaling may affect neuronal activity. It is found that aberrant SSTR3 expression perturbed not only ciliary morphology but also disrupted ciliary signaling cascades. Genetic deletion of SSTR3 resulted in perturbed spatial memory and synaptic plasticity. The axon initial segment (AIS) is a specialized region in the axon where action potentials are initiated. Interestingly, loss of ciliary SSTR3 led to decrease of Akt-dependent cyclic AMP-response element binding protein (CREB)-mediated transcription at the AIS, specifically downregulating AIS master organizer adaptor protein ankyrin G (AnkG) expression. In addition, alterations of other ciliary proteins serotonin 6 receptor (5-HT6R)and intraflagellar transport protein 88 (IFT88) also induced length changes of the AIS. The findings elucidate a specific interaction between the primary cilia and AIS, providing insight into the impact of the primary cilia on neuronal excitability and circuit integrity.
(© 2025 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)