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Treffer: Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm.

Title:
Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm.
Authors:
Silva de França F; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.; Center of Toxins, Cell Signaling and Immune Response (CeTICS) - CEPID - FAPESP, São Paulo, Brazil., de Oliveira Orsi R; Center of Education, Science and Technology in Rational Beekeeping (NECTAR), College of Veterinary Medicine and Animal Sciences, São Paulo State University, Botucatu, São Paulo, Brazil., Fernandes DC; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.; Center of Toxins, Cell Signaling and Immune Response (CeTICS) - CEPID - FAPESP, São Paulo, Brazil., Leonel TB; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.; Center of Toxins, Cell Signaling and Immune Response (CeTICS) - CEPID - FAPESP, São Paulo, Brazil., Tambourgi DV; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.; Center of Toxins, Cell Signaling and Immune Response (CeTICS) - CEPID - FAPESP, São Paulo, Brazil.
Source:
Frontiers in immunology [Front Immunol] 2024 Nov 13; Vol. 15, pp. 1463471. Date of Electronic Publication: 2024 Nov 13 (Print Publication: 2024).
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Imprint Name(s):
Original Publication: [Lausanne : Frontiers Research Foundation]
MeSH Terms:
Bee Venoms*/immunology , Complement Activation*, Bees/immunology ; Complement System Proteins/immunology ; Complement System Proteins/metabolism ; Insect Bites and Stings/immunology ; Complement Pathway, Alternative/immunology ; Animals ; Humans
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Contributed Indexing:
Keywords: Africanized honeybee; Apis mellifera venom; anaphylatoxins; complement pathways activation; immunopathology
Substance Nomenclature:
0 (Bee Venoms)
9007-36-7 (Complement System Proteins)
Entry Date(s):
Date Created: 20241128 Date Completed: 20241128 Latest Revision: 20241130
Update Code:
20260130
PubMed Central ID:
PMC11598452
DOI:
10.3389/fimmu.2024.1463471
PMID:
39606222
Database:
MEDLINE

Weitere Informationen

Introduction: Complement activation split products are signatures of many immunopathological disorders. Among the laboratory findings observed in these diseases, a reduction in the level of circulating intact complement components can be mentioned, and this change has also been detected in envenomation by multiple Africanized honeybee (Apis mellifera) stings. Although envenomation by these animals elicits diverse life-threatening reactions, the capacity of bee venom (AmV) to activate the human complement system remains elusive.
Methods and Findings: By coupling immunochemical and functional approaches, it was observed that AmV strongly consumes components of the alternative pathway (AP) of the complement system in normal human serum (NHS). Additionally, AmV interfered with classical (CP) and lectin pathways (LP) activities. In parallel, a high increase in Ba fragment levels was detected, suggesting that the changes in AP activity were due to its activation. Furthermore, an increase in the level of the C1s-C1INH complex and a decrease in the physiological level of MASP1-C1INH suggested that CP and LP were also activated in the presence of AmV. Strikingly, NHS exposed to increasing AmV concentrations varying from 5 to 1000 µg/mL presented a high generation of C3a, C4a and C5a anaphylatoxins, and sC5b-9 complexes assembly, thus reinforcing that AmV triggers complement activation.
Conclusion: These results show that AmV is a strong complement activator. This activation presents a mixed profile, with a predominance of AP activation. This suggests that complement split products can play important roles in the envenomation by Africanized honeybee, as they could induce diverse immunopathological events observed in patients and may also dictate patient clinical prognosis.
(Copyright © 2024 Silva de França, de Oliveira Orsi, Fernandes, Leonel and Tambourgi.)

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.