*Result*: Neuromodulation of Na+ channels: an unexpected form of cellular plasticity.
Title:
Neuromodulation of Na+ channels: an unexpected form of cellular plasticity.
Authors:
Cantrell AR; Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA., Catterall WA
Source:
Nature reviews. Neuroscience [Nat Rev Neurosci] 2001 Jun; Vol. 2 (6), pp. 397-407.
Publication Type:
Journal Article; Review
Language:
English
Journal Info:
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962781 Publication Model: Print Cited Medium: Print ISSN: 1471-003X (Print) Linking ISSN: 1471003X NLM ISO Abbreviation: Nat Rev Neurosci Subsets: MEDLINE
Imprint Name(s):
Original Publication: London, UK : Nature Pub. Group
MeSH Terms:
Action Potentials/*physiology , Neuronal Plasticity/*physiology , Neurons/*metabolism , Sodium Channels/*metabolism , Synaptic Transmission/*physiology, Action Potentials/drug effects ; Brain/drug effects ; Brain/metabolism ; Brain/ultrastructure ; Neuronal Plasticity/drug effects ; Neurons/drug effects ; Neurons/ultrastructure ; Sodium Channels/drug effects ; Synaptic Transmission/drug effects ; Animals ; Humans ; Phosphorylation
Number of References:
117
Substance Nomenclature:
0 (Sodium Channels)
Entry Date(s):
Date Created: 20010605 Date Completed: 20010726 Latest Revision: 20220309
Update Code:
20260130
DOI:
10.1038/35077553
PMID:
11389473
Database:
MEDLINE
*Further Information*
*Voltage-gated Na+ channels set the threshold for action potential generation and are therefore good candidates to mediate forms of plasticity that affect the entire neuronal output. Although early studies led to the idea that Na+ channels were not subject to modulation, we now know that Na+ channel function is affected by phosphorylation. Furthermore, Na+ channel modulation is implicated in the control of input-output relationships in several types of neuron and seems to be involved in phenomena as varied as cocaine withdrawal, hyperalgesia and light adaptation. Here we review the available evidence for the regulation of Na+ channels by phosphorylation, its molecular mechanism, and the possible ways in which it affects neuronal function.*