Treffer: An Explainable AI Framework for Corneal Imaging Interpretation and Refractive Surgery Decision Support.

This study introduces an explainable neuro-symbolic and large language model (LLM)-driven framework for intelligent interpretation of corneal topography and precision surgical decision support. In a prospective cohort of 20 eyes, comprehensive IOLMaster 700 reports were analyzed through a four-stage pipeline: (1) automated extraction of key parameters—including corneal curvature, pachymetry, and axial biometry; (2) mapping of these quantitative features onto a curated corneal disease and refractive-surgery knowledge graph; (3) Bayesian probabilistic inference to evaluate early keratoconus and surgical eligibility; and (4) explainable multi-model LLM reporting, employing DeepSeek and GPT-4.0, to generate bilingual physician- and patient-facing narratives. By transforming complex imaging data into transparent reasoning chains, the pipeline delivered case-level outputs within ~95 ± 12 s. When benchmarked against independent evaluations by two senior corneal specialists, the framework achieved 92 ± 4% sensitivity, 94 ± 5% specificity, 93 ± 4% accuracy, and an AUC of 0.95 ± 0.03 for early keratoconus detection, alongside an F1 score of 0.90 ± 0.04 for refractive surgery eligibility. The generated bilingual reports were rated ≥4.8/5 for logical clarity, clinical usefulness, and comprehensibility, with representative cases fully concordant with expert judgment. Comparative benchmarking against baseline CNN and ViT models demonstrated superior diagnostic accuracy (AUC = 0.95 ± 0.03 vs. 0.88 and 0.90, p < 0.05), confirming the added value of the neuro-symbolic reasoning layer. All analyses were executed on a workstation equipped with an NVIDIA RTX 4090 GPU and implemented in Python 3.10/PyTorch 2.2.1 for full reproducibility. By explicitly coupling symbolic medical knowledge with advanced language models and embedding explainable artificial intelligence (XAI) principles throughout data processing, reasoning, and reporting, this framework provides a transparent, rapid, and clinically actionable AI solution. The approach holds significant promise for improving early ectatic disease detection and supporting individualized refractive surgery planning in routine ophthalmic practice. [ABSTRACT FROM AUTHOR]